苦参碱与氧化苦参碱对骨骼及关节疾病临床药理作用的研究进展

Research Progress in Clinical Pharmacological Effects of Matrine and Oxymatrine on Bone and Joint Diseases

苦参碱和氧化苦参碱具有抗炎和免疫调节作用,可抑制关节滑膜成纤维细胞增殖、侵袭和关节炎症,可用于防治骨性关节炎和类风湿性关节炎。苦参碱和氧化苦参碱均能阻滞巨噬细胞和单个核细胞分化成破骨细胞,不抑制成骨细胞分化,减轻骨形成和骨吸收之间的失衡引起的骨质丢失,提高骨密度,可防治骨质疏松和关节的退行性改变。苦参碱和氧化苦参碱还有抗肿瘤作用和镇痛作用,临床上已被用于治疗骨癌疼痛。该文综述了苦参碱和氧化苦参碱在骨骼和关节疾病临床治疗中的研究进展,为临床治疗提供参考。

Matrine and oxymatrine have effects of anti-inflammation and immunoregulation,and can inhibit proliferation and invasion of synovial fibroblasts and inflammation of articulation,and can prevent and treat for osteoarthritis and rheumatoid arthritis. Matrine and oxymatrine block macrophage and monocyte to differentiate to osteoclast,and do not block differentiation of osteoblast,and decrease bone loss induced by the imbalance between osteogenesis and bone absorption,and increase bone density,and can prevent and treat for osteoporosis and articular retrograde degeneration.Martine and oxymatrine have the effects of anti-tumors and analgesia,and in clinic both of them have been used to treat pain of bone cancer. This article reviews the research progress of matrine and oxymatrine in the clinical treatment of bone and joint diseases so as to provides reference for clinical treatment.