分析急性心肌梗死后室性心律失常采用胺碘酮治疗的疗效

Analysis of the Therapeutic Effect of Amiodarone on Ventricular Arrhythmia after Acute Myocardial Infarction

目的研究胺碘酮治疗急性心肌梗死后室性心律失常的疗效及安全性。方法选取2017年9月—2020年4月该院收治的80例急性心肌梗死后室性心律失常患者,按随机数表法设置对照组(40例)与研究组(40例),对照组给予利多卡因,研究组给予胺碘酮,两组均持续治疗1周。治疗前后对比两组TG、Hcy、AngⅡ水平,心功能指标、临床治疗效果、不良事件。结果治疗前两组TG、AngⅡ、Hcy差异无统计学意义(P>0.05),治疗后研究组TG(1.35±0.32)mmol/L、AngⅡ(38.45±6.50)pg/mL、Hcy(12.06±1.36)mmol/L均低于对照组,差异有统计学意义(t=4.534、6.727、11.456,P<0.05);两组治疗前QRS波时间、PR间期、LVEF相比差异无统计学意义(P>0.05),治疗后研究组QRS波时间(0.07±0.03)s、PR间期(0.13±0.01)s更短,LVEF(0.63±0.12)更高,差异有统计学意义(t=128.05、6.000、17.156,P<0.05);研究组总有效率(93.00%)高于对照组,差异有统计学意义(χ^(2)=4.501,P=0.034);针对并发症发生率,研究组(2.50%)低于对照组,差异无统计学意义(P>0.05);针对满意度的结果显示,研究组(92.5%)高于对照组,差异有统计学意义(χ^(2)=6.646,P=0.010)。结论胺碘酮治疗能有效帮助急性心肌梗死后室性心律失常患者快速恢复健康,减少并发症。

Objective To study the efficacy and safety of amiodarone in the treatment of rentricular arrhythmia after acute myocardial infarction with posterior ventricular arrhythmia.Methods Selectd 80 patients with rentricular arrhythmia after acute myocardial infarction admitted to the hospital from September 2017 to April 2020 to set up the control group(40 cases)and the study group(40 cases)according to the random number table method,and the control group was given lidocaine,the study group was given amiodarone,and both groups continued treatment for 1 week.The levels of TG,Hcy,AngⅡ,cardiac function indexes,clinical treatment effects,and adverse events were compared between the two groups before and after treatment.Results There was no statistically significant difference in TG,AngⅡ,Hcy between the two groups before treatment(P>0.05).After treatment,the study group had TG(1.35±0.32)mmol/L,AngⅡ(38.45±6.50)pg/mL,Hcy(12.06±1.36)mmol/L was lower than the control group,and the difference was statistically significant(t=4.534,6.727,11.456,P<0.05);there was no statistically significant difference in QRS wave time,PR interval,LVEF between the two groups before treatment(P>0.05),after treatment,QRS wave time(0.07±0.03)s,PR interval(0.13±0.01)s was shorter in the study group,and LVEF(0.63±0.12)was higher,the difference was statistically significant(t=128.05,6.000,17.156,P<0.05);the total effective rate of the study group(93.00%)was higher than that of the control group,and the difference was statistically significant(χ^(2)=4.501,P=0.034);regarding the incidence of complications,the study group(2.50%)was lower than the control group,the difference was not statistically significant(P>0.05);the results of satisfaction showed that the study group(92.5%)was higher than the control group,the difference was statistically significant(χ^(2)=6.646,P=0.010).Conclusion Amiodarone therapy can effectively help patients with ventricular arrhythmia after acute myocardial infarction quickly recover their health and reduce complications.