消化内镜联合三联法治疗对胃溃疡出血临床疗效、Hp根除及生活质量影响

The Effect of Digestive Endoscopy Combined with Triple Therapy on the Clinical Efficacy of Gastric Ulcer Bleeding,Hp Eradication and Quality of Life

目的分析消化内镜联合三联法治疗对胃溃疡出血临床疗效、Hp根除及生活质量影响。方法选择2020年1月—2021年1月该院收治的120例胃溃疡出血患者,按随机数表分为两组,对照组60例使用三联法治疗,研究组60例在对照组治疗基础上使用消化内镜治疗,对两组临床疗效、炎症因子水平、再出血率、Hp根除及生活质量进行比较。结果研究组患者临床总有效率为93.33%高于对照组的80.00%,差异有统计学意义(χ^(2)=4.615,P<0.05);研究组治疗后白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、白细胞介素-23(IL-23)等炎症指标分别为(36.10±2.59)、(25.23±2.15)、(17.72±2.60)ρ/(ng·L),均比对照组低,差异有统计学意义(t=9.450、16.960、24.406,P<0.05);研究组再出血率为6.67%比对照组低,Hp根除率高于对照组,差异有统计意义(χ^(2)=4.615,P<0.05);研究组物质生活、躯体功能、心理功能、社会功能等评分分别为(86.83±3.11)分、(87.60±3.25)分、(86.53±3.89)分、(85.19±3.40)分,均比对照组高,差异有统计学意义(t=21.871、17.364、12.394、12.759,P<0.05)。结论临床使用消化内镜联合三联法治疗胃溃疡出血患者,可减轻患者炎症反应水平,降低再出血率和提高Hp根除率,能有效提升其生活质量及临床疗效,临床上值得推广使用。

Objective To analyze the effect of digestive endoscopy combined with triple therapy on gastric ulcer bleeding,Hp eradication and quality of life.Methods From January 2020 to January 2021,120 patients with gastric ulcer bleeding were selected and divided into two groups according to the random number table.60 cases in the control group were treated with triple therapy,and 60 cases in the study group were treated with digestive endoscopy on the basis of the treatment in the control group.The clinical efficacy,inflammatory factor level,rebleeding rate,Hp eradication and quality of life were compared between the two groups.Results The total clinical efficiency of 93.33%in the study group was higher than that in the control group(80.00%),the difference was statistically significant(χ^(2)=4.615,P<0.05).The inflammatory indexes of interleukin-6(IL-6),interleukin-17(IL-17)and interleukin-23(IL-23)in the study group were(36.10±2.59)ρ/(ng·L),(25.23±2.15)ρ/(ng·L)and(17.72±2.60)ρ/(ng·L),respectively,which were lower than those in the control group,the difference was statistically significant(t=9.450,16.960,24.406,P<0.05);the rebleeding rate in the study group was 6.67%lower than that in the control group,and Hp eradication rate was higher than that in the control group,the difference was statistically significant(χ^(2)=4.615,P<0.05).The scores of material life,physical function,psychological function and social function in the study group were(86.83±3.11)points,(87.60±3.25)points,(86.53±3.89)points and(85.19±3.40)points,respectively,which were higher than those in the control group,the difference was statistically significant(t=21.871,17.364,12.394,12.759,P<0.05).Conclusion The clinical use of digestive endoscopy combined with triple therapy in the treatment of patients with gastric ulcer bleeding can reduce the level of inflammatory response,reduce the rate of rebleeding and increase the rate of Hp eradication,and can effectively improve their quality of life and clinical efficacy.It is clinically worthy of promotion.