囊性颌骨成釉细胞瘤应用开窗减压术治疗的临床效果及安全性分析

The Clinical Effect and Safety Analysis of Cystic Ameloblastoma of Jaw with Fenestration Decompression

目的观察开窗减压术治疗颌骨囊性成釉细胞瘤的临床疗效,并对安全性进行分析,探讨开窗减压术的应用价值,为临床治疗提供可靠的理论依据。方法于2016年2月—2019年1月纳入160例研究对象,均在该院口腔科就诊并进行治疗,经影像学和临床鉴别诊断为囊性颌骨成釉细胞瘤的患者,所有患者以随机数字表法的形式,按1∶1原则,80例纳入到观察组中行开窗减压术治疗,80例纳入到对照组中行囊肿刮治术,对两组患者的有效率和复发率进行统计分析,并对比治疗结果。结果观察组总复发率为15.00%,低于对照组的37.50%,差异有统计学意义(χ^(2)=10.460,P=0.001);观察组的总有效率为92.50%,高于对照组的81.25%,差异有统计学意义(χ^(2)=4.440,P=0.035)。结论应用开窗减压术治疗囊性颌骨成釉细胞瘤,临床安全性高,复发率低,有利于临床进一步推广和应用。但是考虑到该研究年限限制,临床样本量较低,因此建议后续研究中可扩大规模,实施研究。

Objective To observe clinical efficacy of fenestration decompression in the treatment of cystic ameloblastoma of the jaw,analyze its safety,explore the application value of fenestration decompression,and provide a reliable theoretical basis for clinical treatment.Methods 160 subjects were included from February 2016 to January 2019.All of whom were treated and treated in the dentistry department of the hospital,and were diagnosed as cystic ameloblastoma of the jaw by clinical imaging and clinical differentiation.In the form of random number table,according to the 1∶1 principle,80 cases were included in the observation group for fenestration decompression,and 80 cases were included in the control group for cyst curettage.The effective rate and recurrence rate of the two groups of patients were statistically analyzed,and the treatment results were compared.Results The two-year recurrence rate was 7.50% in both groups,the difference was not statistically significant(P>0.05);the total recurrence rate of the observation group was 15.00%,which was lower than that of the control group 37.50%,and the difference was statistically significant(χ^(2)=10.460,P=0.001);the total effective rate of the observation group was 92.50%,which was higher than the 81.25% of the control group,the difference was statistically significant(χ^(2)=4.440,P=0.035).Conclusion Fenestration decompression for the treatment of cystic ameloblastoma of the jaw has high clinical safety and low recurrence rate,which is conducive to further clinical promotion and application.However,considering the limited number of years of this study,the clinical sample size is relatively low.Therefore,it is recommended that the scale of follow-up studies be expanded and the study carried out.