西酞普兰治疗老年抑郁症的疗效及对认知功能的影响

Efficacy of Citalopram in the Treatment of Senile Depression and Its Effect on Cognitive Function

目的探讨西酞普兰治疗老年抑郁症的临床效果及对认知功能的影响。方法选取2019年10月—2020年12月在该院住院的老年抑郁症患者156例,随机分为对照组和治疗组,对照组给予安慰剂,治疗组给予西酞普兰,采用临床疗效总评量表和汉密尔顿抑郁量表评价西酞普兰治疗老年抑郁症的临床效果,应用Oxford Medelec Synergy肌电/诱发电位仪进行事件相关电位P300检测和威斯康星卡片分类检测(WCST)评定患者的认知功能,以副反应量表(TESS)分析两组不良反应情况差异。结果治疗前,两组患者的抑郁状况和认知能力差异无统计学意义(P>0.05),8周治疗结束后,治疗组6例显效,65例有效,7例无效,总有效率达91.03%,对照组无显效,29例有效,49例无效,总有效率达37.18%,两组差异有统计学意义(χ^(2)=49.140,P<0.05)。与对照组相比,治疗组的HAMD-17评分、CGI-GI评分明显低于对照组的评分,差异有统计学意义(P<0.05),治疗组的认知功能损害得到显著改善,两组与药物相关的不良反应评分差异无统计学意义(P>0.05)。结论西酞普兰能够显著改善老年抑郁状况和认知能力,且药物不良反应较小,具有一定的临床价值。

Objective To investigate the clinical effect of citalopram in the treatment of senile depression and its influence on cognitive function.Methods A total of 156 elderly depression patients who were hospitalized in the hospital from October 2019 to December 2020 were selected and randomly divided into a control group and a treatment group.The control group was given a placebo and the treatment group was given citalopram.The overall clinical efficacy scale was used.And Hamilton depression scale to evaluate the clinical effect of citalopram in the treatment of elderly depression.Oxford Medelec Synergy electromyography/evoked potential meter was used for event-related potential P300 detection and Wisconsin card sorting test(WCST)to evaluate the cognitive function of patients.The treatment emergent symptom scale(TESS)analyzed the differences in adverse reactions between the two groups.Results Before treatment,there was no statistically significant difference in depression and cognitive ability between the two groups of patients(P>0.05).After 8 weeks of treatment,6 cases in the treatment group were effective,65 cases were effective,and 7 cases were ineffective,the total effective rate was 91.03%.No case in the control group was effective,29 cases were effective,and 49 cases were ineffective,the total effective rate was 37.18%,the difference between the two groups was statistically significant(χ^(2)=49.140,P<0.05).Compared with the control group,the HAMD-17 score and CGI-GI score of the treatment group were significantly lower than those of the control group.The difference was statistically significant(P<0.05).The cognitive impairment of the treatment group was significantly improved.There was no significant difference in the scores of drug-related adverse reactions between the two groups(P>0.05).Conclusion Citalopram can significantly improve the elderly depression and cognitive ability,and the adverse reactions of the drug are small,which has certain clinical value.