门冬胰岛素、甘精胰岛素联合治疗小儿1型糖尿病的疗效分析

Analysis of the Curative Effect of the Combination of Insulin Aspart and Insulin Glargine in the Treatment of Type 1 Diabetes in Children

目的分析门冬胰岛素联合甘精胰岛素治疗1型糖尿病(T1DM)患儿的疗效。方法选取2020年1—12月该院收治的T1DM患儿64例为研究对象,依据随机数表法分为两组,对照组(32例,仅用门冬胰岛素),观察组(32例,门冬胰岛素联合甘精胰岛素治疗),对比两组不同疗法治疗前后的糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、血糖波动情况、胰岛素用量以及低血糖发生概率。结果治疗前,两组FPG、2 hPG、HbA1c水平差异无统计学意义(P>0.05);治疗后,两组FPG、2 hPG、HbA1c水平均较治疗前降低,差异有统计学意义(P<0.05);治疗后观察组FPG、2 hPG、HbA1c水平低于对照组,差异有统计学意义(P<0.05),血糖波动幅度小于对照组,且胰岛素用量少于对照组,差异有统计学意义(P<0.05)。观察组低血糖发生概率低于对照组,差异有统计学意义(P<0.05)。结论门冬胰岛素联合甘精胰岛素治疗T1DM患儿疗效确切,能降低血糖水平,减少胰岛素用量并降低低血糖的发生概率,控制血糖波动,值得采用。

Objective To analyze the efficacy of insulin aspart combined with insulin glargine in the treatment of children with type 1 diabetes(T1 DM). Methods 64 children with T1 DM treated in the hospital from January to December 2020 were selected as the research object. According to the random number table method, they were divided into two groups: the control group(32 cases, only insulin aspart) and the observation group(32 cases, insulin aspart combined with insulin glargine). The glycated hemoglobin(HbA1 c), fasting blood glucose(FPG), postprandial 2 h blood glucose(2 hPG), blood glucose fluctuations, insulin dosage, and the incidence of hypoglycemia were compared between the two groups before and after treatment with different therapies. Results Before treatment, there was no statistically significant difference in the levels of FPG, 2 hPG, and HbA1 c between the two groups(P>0.05). After treatment, the levels of FPG, 2 hPG and HbA1 c in the two groups were lower than before treatment, and the difference was statistically significant(P<0.05);the levels of FPG, 2 hPG, and HbA1 c in the observation group were lower than those of the control group, and the difference was statistically significant(P<0.05), the blood glucose fluctuation range was smaller than that of the control group, and the insulin consumption was less than that of the control group, and the difference was statistically significant(P<0.05). The incidence of hypoglycemia in the observation group was lower than that in the control group, and the difference was statistically significant(P <0.05). Conclusion Insulin aspart combined with insulin glargine has a definite effect in the treatment of children with T1 DM. It can lower blood glucose levels, reduce insulin dosage, reduce the incidence of hypoglycemia, and control blood glucose fluctuations. It is worthy of use.