干预性抗菌药物治疗对骨科围术期预防感染及炎症因子水平的影响

The Effect of Interventional Antimicrobial Therapy on the Prevention of Infection and the Level of Inflammatory Factors during the Perioperative Period of Orthopedics

目的探究干预性抗菌药物治疗对骨科围术期预防感染及炎症因子水平的影响。方法选取2018年2月—2021年3月在该院行骨科手术的102例患者为研究对象。基于随机抽签规则,均分为对照组及观察组。对照组给予常规围术期治疗;观察组给予干预性抗菌药物治疗。对比两组不良事件发生情况、治疗前后炎症因子指标水平以及治疗满意率情况。结果治疗后,观察组CRP(9.31±4.73)mg/L、TNF-α(41.65±7.12)pg/mL、WBC(10.02±1.33)×10^(9)/L及IL-6(161.56±13.77)pg/mL均大幅度低于对照组(15.11±5.85)mg/L、(69.28±7.42)pg/mL、(13.11±1.63)×10^(9)/L、(231.72±13.64)pg/mL,差异有统计学意义(t=5.506、19.188、10.489、25.851,P<0.05);观察组不良事件发生率(3.92%)显著低于对照组(15.69%),差异有统计学意义(χ^(2)=3.991,P=0.046);观察组治疗满意率(94.12%)显著高于对照组(80.39%),差异有统计学意义(χ^(2)=4.320,P=0.038)。结论干预性抗菌药物治疗能有效降低围术期感染等不良事件发生率并有效控制炎症因子水平,提高治疗满意率。

Objective To explore the effect of interventional antimicrobial therapy on the prevention of infection and the level of inflammatory factors during the perioperative period of orthopedics.Methods 102 patients who underwent orthopaedic surgery in the hospital from February 2018 to March 2021 were selected as the research objects.Based on the random drawing rules,they were divided into control group and observation group.The control group was given routine perioperative treatment,the observation group was treated with intervention antibiotics.The incidence of adverse events,the level of inflammatory factors before and after treatment and the treatment satisfaction rate were compared between the two groups.Results After treatment,the observation group CRP(9.31±4.73)mg/L,TNF-α(41.65±7.12)pg/mL,WBC(10.02±1.33)×10^(9)/L and IL-6(161.56±13.77)pg/mL were significantly lower than those in the control group(15.11±5.85)mg/L,(69.28±7.42)pg/mL,(13.11±1.63)×10^(9)/L,(231.72±13.64)pg/mL,the difference was statistically significant(t=5.506,19.188,10.489,25.851,P<0.05).The incidence of adverse events in the observation group(3.92%)was significantly lower than that in the control group(15.69%),the difference was statistically significant(χ^(2)=3.991,P=0.046).The treatment satisfaction rate of the observation group(94.12%)was significantly higher than that of the control group(80.39%),the difference was statistically significant(χ^(2)=4.320,P=0.038).Conclusion Interventional antimicrobial therapy can effectively reduce the incidence of perioperative infections and other adverse events,effectively control the level of inflammatory factors,and improve the satisfaction rate of treatment.