参附注射液治疗休克的临床研究

Clinical Study of Shenfu Injection in the Treatment of Shock

目的研究分析休克患者应用参附注射液治疗的临床效果。方法选取2018年1月—2021年3月在该院治疗的休克患者60例为研究对象,依据数表法随机分为两组,组别为对照组与研究组。对照组患者(30例)应用常规治疗,研究组患者(30例)应用参附注射液治疗,以患者血流动力学、内皮功能、炎症因子为观察指标,并对两组观察结果予以统计比较。结果研究组治疗后血氧饱和度(SpO_(2))、平均动脉压(MAP)数值分别为(92.05±4.11)%、(70.72±3.38)mmHg,均高于对照组;心率(HR)数值为(72.36±4.28)次/min,低于对照组,组间比较差异有统计学意义(t=6.420、9.908、18.335,P<0.05)。研究组治疗后内皮素-1(ET-1)数值为(52.17±5.18)μg/L,低于对照组;一氧化氮(NO)数值为(53.89±4.27)μg/L,高于对照组,组间对比差异有统计学意义(t=14.554、11.049,P<0.05)。研究组治疗后降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)数值分别为(1.73±0.43)ng/L、(7.52±1.18)mg/L、(6.19±1.62)ng/L、(0.18±0.04)μg/L,均低于对照组,组间比较差异有统计学意义(P<0.05)。结论参附注射液治疗休克患者的效果十分显著,不仅可以改善患者血流动力学与内皮功能,还可以减轻患者炎症反应,提高患者预后,值得临床推荐应用。

Objective To study and analyze the clinical effect of Shenfu injection in shock patients.Methods A total of 60 shock patients treated in the hospital from January 2018 to March 2021 were selected as the research objects.According to the number table method,they were randomly divided into two groups,the control group and the study group.Patients in the control group(30 cases)were treated with conventional treatment,and patients in the study group(30 cases)were treated with Shenfu injection.The patient’s hemodynamics,endothelial function,inflammatory factors were used as observation indicators,and the observation results of the two groups were statistically compared.Results The blood oxygen saturation(SpO2)and mean arterial pressure(MAP)values of the study group after treatment were(92.05±4.11)%and(70.72±3.38)mmHg,respectively,which were higher than those of the control group.The heart rate(HR)value was(72.36±4.28)beats/min,which was lower than that of the control group,and the difference between the groups was statistically significant(t=6.420,9.908,18.335,P<0.05).After treatment,the endothelin-1(ET-1)value of the study group was(52.17±5.18)μg/L,which was lower than that of the control group.The value of nitric oxide(NO)was(53.89±4.27)μg/L,which was higher than that of the control group,and the difference between the groups was statistically significant(t=14.554,11.049,P<0.05).The values of procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in the study group after treatment were(1.73±0.43)ng/L,(7.52±1.18)mg/L,(6.19±1.62)ng/L,(0.18±0.04)μg/L,all lower than the control group,the difference between the groups was statistically significant(P<0.05).Conclusion Shenfu injection is very effective in treating shock patients.It can not only improve the hemodynamics and endothelial function of the patients,but also reduce the inflammation of the patients and improve the prognosis of the patients.It is worthy of clinical recommendation.