不同剂量右美托咪定对小儿腹部手术后躁动与氧化应激反应的影响

Effects of different doses of dexmedetomidine on agitation and oxidative stress reaction after abdominal surgery in children

目的分析小儿腹部外科手术不同剂量右美托咪定对术后躁动与氧化应激反应的影响。方法 2019年1月~2020年9月全身麻醉下行腹部手术的患儿175例,采用随机数表法分为A、B、C、D、E共5组,每组35例。A、B、C、D组麻醉诱导中应用0.4μg/kg、0.6μg/kg、0.8μg/kg及1.0μg/kg剂量右美托咪定,E组给予0.9%氯化钠溶液。记录各组肾上腺素、胰高血糖素、血糖以及皮质醇等氧化应激反应的相关指标水平,记录各组躁动评分及术后镇痛和镇静评分。结果 A、B、C、D 4组躁动评分显著低于E组,差异有统计学意义(P<0.05);B、C、D 3组术后镇静和镇痛情况显著好于A、E两组,差异有统计学意义(P<0.05)。结论小儿腹部外科手术中给予右美托咪定的最佳剂量为0.8μg/kg。

Objective To analyze the effects of different doses of dexmedetomidine on postoperative agitation and oxidative stress in children undergoing abdominal surgery.Methods Totally 175 children undergoing abdominal surgery under general anesthesia in our hospital from January 2019 to September 2020 were randomly divided into 5 groups, with 35 cases in each group, by random number table method.Dexmedetomidine(0.4 μg/kg, 0.6 μg/kg, 0.8 μg/kg and 1.0 μg/kg)was used in the first four groups during anesthesia induction.The levels of adrenaline, glucagon, blood glucose and cortisol;and the postoperative analgesia and sedation scores were evaluated.Results Restlessness score in group A to D was significantly lower than that in group E(P<0.05);postoperative sedation and analgesia in group B,C and D were significantly better than those in group A and E(P<0.05).Conclusion The optimal dose of dexmedetomidine in pediatric abdominal surgery is 0.8 μg/kg.