摘要
【目的】制备复方紫草温敏凝胶并对其进行质量评价。【方法】采用冷溶法,以泊洛沙姆为基质制备复方紫草温敏凝胶。将胶凝温度作为考察指标对所制凝胶进行处方优化。从凝胶的理化性质、微生物限度等方面对所制备的凝胶制剂进行质量评价。【结果】所得复方紫草温敏凝胶的最佳处方为:16%P407+2%P188+4%甘油+8%复方紫草药液,平均胶凝温度为32.8℃。【结论】所制备复方紫草温敏凝胶质量稳定、胶凝温度合适,可为各种创伤的愈合提供更好的新选择。
【Objective】To prepare and evaluate the warm sensitive gel of compound‘Zicao’.【Method】The warm sensitive gel of compound‘Zicao’was prepared with Poloxamer by cold solution. Taking the gelation temperature as an index,the formulation of the gel was optimized. The quality of the prepared gel was evaluated according to physicochemical property,and the microbial limit.【Result】The best prescription of the warm sensitive gel was prepared by 16% P407,2% P188,4% glycerol and 8% compound‘Zicao’extraction. The average gelation temperature of 32.8 ℃ was obtained.【Conclusion】The compound‘Zicao’warm sensitive gel is stable in quality and suitable in gelation temperature,providing a better new choice for the healing of various wounds.
作者
徐科
吴赟杰
李金洋
赵君晰
张泽瀚
梁晓霞
XU Ke;WU Yunjie;LI Jinyang;ZHAO Junxi;ZHANG Zehan;LIANG Xiaoxia(Natural Medicine Research Center,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China)
出处
《四川农业大学学报》
CSCD
北大核心
2021年第6期791-798,共8页
Journal of Sichuan Agricultural University
基金
省级大学生创新训练计划项目(202010626091)。
关键词
紫草复方
温敏凝胶
质量评价
冷溶法
处方优化
compound‘Zicao’
warm sensitive gel
quality evaluation
cold solution
prescription optimization