氨溴索联合鼻塞式持续气道正压对肺透明膜病早产儿IL-6、IL-8水平的影响

Impact of Ambroxol Combined with Nasal Continuous Positive Airway Pressure on IL-6 and IL-8 Levels of Premature Infants with Hyaline Membrane Disease

目的探讨氨溴索联合鼻塞式持续气道正压(NCPAP)治疗肺透明膜病(HMD)早产儿的效果。方法68例HMD早产儿随机均分为两组各34例,对照组给予NCPAP治疗,观察组给予氨溴索联合NCPAP治疗,比较两组治疗前后的血气指标和炎性因子水平。结果治疗后,观察组的PaCO_(2)、IL-6、IL-8和TNF-α水平均显著低于对照组,PaO_(2)和PaO_(2)/FiO_(2)水平均显著高于对照组(P<0.05)。结论氨溴索联合NCPAP治疗HMD早产儿效果显著,可改善血气指标,降低炎性因子水平。

Objective To explore the effect of ambroxol combined with NCPAP in the treatment of premature infants with hyaline membrane disease(HMD).Methods 68 premature infants with HMD were randomly divided into two groups,with 34 cases in each group.The control group was treated with NCPAP,while the observation group was treated with ambroxol combined with NCPAP.The levels of blood gas indicators and inflammatory factors were compared between the two groups.Results After treatment,the levels of PaCO_(2),IL-6,IL-8 and TNF-α in the observation group were significantly lower than those in the control group,and the levels of PaO_(2)and PaO_(2)/FiO_(2)were significantly higher than those in the control group(P<0.05).Conclusions Ambroxol combined with NCPAP in the treatment of premature infants with HMD has significant effect,and can improve blood gas indicators and reduce the levels of inflammatory factors.