阿加曲班联合阿司匹林、氯吡格雷治疗对急性脑梗死患者血液流变学指标及神经功能的影响

Impact of Argatroban Combined with Aspirin and Clopidogrel Treatment on Hemorheology Indicators and Neurological Function in Patients with Acute Cerebral Infarction

目的探讨阿加曲班联合阿司匹林、氯吡格雷治疗对急性脑梗死(ACI)患者血液流变学指标及神经功能的影响。方法78例ACI患者随机分为两组各39例,对照组采用阿司匹林联合氯吡格雷治疗,观察组在对照组基础上采用阿加曲班治疗,比较两组的血液流变学指标和神经功能缺损情况。结果治疗1周后,两组的血浆黏度、全血低切粘度、纤维原蛋白水平以及NIHSS评分均显著低于治疗前,且观察组的各指标均显著低于对照组(P<0.05)。结论阿加曲班联合阿司匹林、氯吡格雷治疗急性脑梗死的效果显著,可显著降低患者的血液流变学指标,改善患者的神经功能。

Objective To explore the impact of argatroban combined with aspirin and clopidogrel treatment on hemorheology indicators and neurological function in patients with acute cerebral infarction(ACI).Methods 78 ACI patients were randomly divided into two groups,with 39 cases in each group.The control group was treated with aspirin combined with clopidogrel,and the observation group was treated with argatroban on the basis of the control group.The hemorheology indicators and neurological deficits were compared between the two groups.Results After 1 week of treatment,the levels of plasma viscosity,whole blood low shear viscosity and fibrinogen,and NIHSS score of the two groups were significantly lower than those before treatment,and the above indicators of the observation group were significantly lower than those of the control group(P<0.05).Conclusions Argatroban combined with aspirin and clopidogrel has significant effect in the treatment of ACI,which can effectively reduce hemorheology indicators,and improve the neurological function of patients.