新生儿高胆红素血症换血疗法后实验室检测指标的变化分析

Analysis on the Changes of Laboratory Test Indicators After Blood Exchange Therapy for Neonatal Hyperbilirubinemia

目的探讨新生儿高胆红素血症换血疗法后的实验室检测指标变化。方法选取2018年1月至2020年12月我院收治的50例高胆红素血症新生儿为对象,均行换血疗法,分析换血前后的血常规、生化、凝血功能指标水平。结果换血后,白细胞计数、血小板计数、网织红细胞水平均较换血前降低,红细胞计数、血红蛋白水平均较换血前升高(P<0.05)。换血后,总胆红素、直接胆红素、间接胆红素、钾、钙水平均较换血前降低(P<0.05)。换血后,纤维蛋白原、D-二聚体水平均较换血前降低(P<0.05)。结论换血疗法可降低高胆红素血症新生儿的胆红素水平,缓解临床症状。

Objective To explore the changes of laboratory test indicators after blood exchange therapy for neonatal hyperbilirubinemia.Methods 50 neonates with hyperbilirubinemia admitted to our hospital from January 2018 to December 2020 were selected as objects.All cases received blood exchange therapy.The levels of blood routine,biochemistry and coagulation indicators before and after blood exchange were analyzed.Results After blood exchange,the white blood cell count,platelet count and reticulocyte levels were lower than those before blood exchange,and the red blood cell count and hemoglobin levels were higher than those before blood exchange(P<0.05).After blood exchange,the total bilirubin,direct bilirubin,indirect bilirubin,potassium and calcium levels were lower than those before blood exchange(P<0.05).After blood exchange,the fibrinogen and D-dimer levels were lower than those before blood exchange(P<0.05).Conclusions Blood exchange therapy can reduce the bilirubin level of neonates with hyperbilirubinemia and relieve clinical symptoms.