基于医院信息系统的真实世界研究主题分析

Thematic Analysis of the Real-World Study Based on Hospital Information System

目的对基于医院信息系统的真实世界研究进行主题分析,为未来基于医院信息系统开展相关研究提供借鉴和参考。方法检索中国知网、万方数据知识服务平台、中国生物医学文献服务系统、维普中文期刊平台、PubMed数据库、EMBASE数据库,获取基于医院信息系统的真实世界研究。用VOS viewer 1.6.15版软件对纳入研究的关键词、作者、发表机构、发表期刊等字段进行提取,并生成高频关键词聚类网络图以及作者、机构的合作网络图。利用Microsoft Visio软件绘制研究内容思维导图。结果367篇基于医院信息系统的真实世界研究刊载在134种期刊上,其中《中国中药杂志》载文量最多。发文量最多的作者和机构分别是谢雁鸣研究员和中国中医科学院,存在合作关系作者和机构分别形成5个作者合作团体、14个机构合作体。关键词网络图显示基于医院信息系统的真实世界研究主要聚焦6个主题,关键词密度图表明研究的热度最高的是医院信息系统、真实世界、联合用药和倾向性评分法。研究频次最高的前3种药物是复方苦参注射液、参附注射液、灯盏细辛注射液,关注度最高的系统疾病、疾病分别是消化系统疾病和冠心病。基于医院信息系统的真实世界研究涉及6个方面:疾病或药物临床特征、药物评价、影响因素、干预效果评价、相关性研究以及探索性研究。使用频率最高的分析方法是描述性分析和关联分析联合使用。结论我国基于医院信息系统的真实世界研究仍处于起步阶段,研究者关注度较低,各个机构和作者之间合作相对匮乏;研究方法、数据分析方法单一,数据利用率低;主要关注内容为用药特征、临床疾病特征、药物评价,但多关注其外部特征,对内部规律研究较少,且西医真实世界研究关注度有待提高。

Objective To conduct a thematic analysis of the real-world study based on hospital information system,in order to provide reference for further studies.Methods CNKI,Wanfang Data,SinoMed,VIP,PubMed,EMBASE databases for real-world studies based on hospital information system were searched.The main contents,such as keywords,authors,organizations,journals,were extracted by the VOS viewer 1.6.15 software as well as generated a high-frequency keywords clustering network map and a cooperation network map of authors and organizations.The Microsoft Visio software was used to draw a mind map of the research content.Results A total of 367 real-world studies based on hospital information systems were published in 134 journals,of which the Zhongguo zhongyao zazhi was the most productive journal.The authors and institutions with the most publications are Researcher Xie Yanming and the China Academy of Chinese Medical Sciences,respectively.The authors and institutions that have a cooperative relationship have formed 5 author cooperative groups and 14 institutional cooperative bodies,respectively.The keywords network diagram showed that the real-world studies based on the hospital information system mainly focuses on six topics,and the keyword density diagram showed that hospital information system,real world,combination medication and propensity scoring method were the most popular contents.The top three of most frequency drugs were Compound Kushen Injection,Shenfu Injection,and Dengzhan xixin Injection,respectively.The most concerned system disease and disease were digestive system diseases and coronary heart disease,respectively.The real-world studies based on hospital information system mainly concerned six aspects:clinical characteristics of diseases or drugs,drug evaluation,influencing factors,intervention effect evaluation,correlation studies and exploratory studies.The most frequently used analysis method was the descriptive analysis combined with the association analysis.Conclusion Chinese real-world study based on hospital information systems is still in its infancy.The attention of researchers is low,and the cooperation between various institutions and authors is relatively lacking.The research methods and data analysis methods are simple and crude,and the data utilization rate is low.The most concerned aspects are usage characteristics of drugs,clinical characteristics of diseases,and drugs evaluation,however pay more attention to its external characteristics,less research on internal laws,and the degree of attention to the real world research of western medicine needs to be improved.