摘要
哺乳动物雷帕霉素靶蛋白(mTOR)能感受外界各种信号(如缺氧、应激、营养素等),调节机体代谢(包括细胞的生长、存活等),影响生物功能。该文综述了mTOR抑制药雷帕霉素在癌症、代谢、寿命等方面的药理作用,为其临床应用提供参考。
Mammalian rapamycin target protein(mTOR)can sense various external signals(hypoxia,stress,nutrients,etc.),regulate body metabolism(including cell growth,survival,etc.),and affect biological functions.This paper reviews the different role of rapamycin,an inhibitor of mTOR,in cancer,metabolism,life span and so on.Furthermore,it provides reference for its clinical application.
作者
吴加东
王爱飞
徐又佳
孙焕建
WU Jiadong;WANG Aifei;XU Youjia;SUN Huanjian(Department of Orthopaedics,Yancheng School of Clinical Medicine of Nanjing Medical University,Yancheng 224005,China;Department of Orthopaedics,Clinical College of Jiangsu Medical Vocational College(Yancheng Third People's Hospital),Yancheng 224005,China;Department of Orthopaedics,the Second Affiliated Hospital of Suzhou University,Suzhou 215200,China)
出处
《医药导报》
CAS
北大核心
2022年第1期99-102,共4页
Herald of Medicine
基金
江苏医药职业学院临床教学基地科研发展专项课题(17)。
