生物可降解镁合金骨科植入材料的临床应用及其有限元分析

Clinical application and finite element analysis of biodegradable magnesium alloy orthopedic implants

在骨-器械界面建立和维持成熟骨是骨科植入材料长期成功的关键.镁合金由于其生物可降解性、天然骨组织的力学相似性以及成骨潜力,并且在体内不抑制间充质干细胞(hBMSCs)的成骨特性,成为有前途的承重骨科植入物的候选材料.但其高降解率和植入物相关感染的风险以及不佳的力学性能,对其临床应用提出了巨大的挑战.有限元分析方法能对复杂结构、形态、载荷和材料力学性能进行应力分析,可有效地帮助临床医生了解镁合金植入器械的应力及生物力学性能.

The establishment and maintenance of mature bone at the bone-device interface are critical to the long-term success of orthopedic implant materials. Magnesium alloys are promising candidate materials for weight-bearing orthopedic implants because of their biodegradability, mechanical similarity to natural bone tissue, osteogenic potential, and non-inhibition of the osteogenic properties of human bone mesenchymal stem cells(hBMSCs) in vivo. However, the high degradation rate, the risk of implant-related infection and poor mechanical properties pose great challenges to their clinical application. The finite element analysis method can analyze the stress of complex structure, shape, load and mechanical properties of materials, and can effectively help clinicians understand the stress and biomechanical properties of magnesium alloy implanted devices.