琥珀酸美托洛尔缓释片治疗心梗后室性心律失常的效果观察

Effect of metoprolol succinate sustained-release tablets in the treatment of ventricular arrhythmia after myocardial infarction

目的探讨在心肌梗死(心梗)后室性心律失常的治疗中实施琥珀酸托洛尔方案的临床效果。方法80例心梗后室性心律失常患者,依据患者入院编号的奇偶性分为实验组与参照组,各40例。参照组实施传统对症治疗,实验组在参照组基础上行琥珀酸美托洛尔缓释片治疗。比较两组临床治疗效果、治疗前后相关临床指标。结果实验组治疗总有效率为97.50%,高于参照组的82.50%,差异有统计学意义(χ2=5.000,P=0.025<0.05)。治疗后,两组QT间期离散度(QTd)、校正QT间期离散度(QTcd)、心率、SF-36评分均较治疗前改善,且实验组QTd(42.38±1.56)ms、QTcd(50.45±4.66)ms、心率(85.46±7.31)次/min低于参照组的(60.71±1.49)ms、(69.73±5.79)ms、(100.26±8.46)次/min,SF-36评分(80.14±7.93)分高于参照组的(71.57±7.63)分,差异有统计学意义(P<0.05)。结论在心梗后室性心律失常的治疗中,琥珀酸美托洛尔缓释片具备理想的治疗效果,具有重要应用价值。

Objective To discuss the clinical effect of therapeutic schedule of metoprolol succinate sustained-release tablets in the treatment of ventricular arrhythmia after myocardial infarction.Methods 80 patients with ventricular arrhythmia after myocardial infarction were selected and divided into experimental group and control group based on their admission numbers,with 40 cases in each group.Patients in the control group received traditional symptomatic treatment,while patients in the experimental group were administered with metoprolol succinate sustained-release tablets in addition to the conventional treatment to the control group.The clinical effect and relevant clinical indicators before and after the treatment were compared between the two groups.Results The experimental group had an overall therapeutic effective rate of 97.50%,which was higher than 82.50%of the control group,the difference was statistically significant(χ2=5.000,P=0.025<0.05).Compared with the situation before the treatment,the QT dispersion(QTd),the corrected QT dispersion(QTod),heart rate and the score of SF-36 were improved after the treatment.Additionally,the experimental group had QTd of(42.38±1.56)ms,QTcd of(50.45±4.66)ms,heart rate of(85.46±7.31)beats/min,which were lower than(60.71±1.49)ms,(69.73±5.79)ms,(100.26±8.46)beats/min of the control group;the experimental group had(80.14±7.93)points in SF-36,which was higher than(71.57±7.63)points of the control group;and the differences were statistically significant(P<0.05).Conclusion Metoprolol succinate sustained-release tablets have ideal therapeutic effect in the treatment of ventricular arrhythmia after myocardial infarction,so it is of great importance in clinic application.