奥美拉唑联合乌司他丁治疗消化道出血的疗效探讨

Efficacy of omeprazole combined with urinastatin in the treatment of gastrointestinal hemorrhage

目的分析奥美拉唑联合乌司他丁治疗消化道出血的疗效。方法120例消化道出血患者,随机分为对照组和观察组,每组60例。对照组患者给予奥美拉唑治疗,观察组患者给予奥美拉唑联合乌司他丁治疗。比较两组止血时间、腹痛缓解时间、血红蛋白(Hb)复常时间、血压恢复正常时间、大便潜血试验转阴性时间,治疗前后血清学炎症因子水平,临床疗效,不良反应发生情况。结果观察组止血时间(3.60±0.23)d、腹痛缓解时间(1.21±0.12)d、Hb复常时间(5.21±1.12)d、血压恢复正常时间(2.34±0.21)d、大便潜血试验转阴性时间(4.13±0.21)d均短于对照组的(4.65±0.45)、(2.56±0.24)、(7.24±1.21)、(3.45±0.25)、(6.21±0.25)d,差异具有统计学意义(P<0.05)。治疗后,两组患者的超敏C反应蛋白、肿瘤坏死因子-α、白细胞计数、白细胞介素-6均显著低于治疗前,Hb水平均显著高于治疗前,差异具有统计学意义(P<0.05)。治疗后,观察组超敏C反应蛋白、肿瘤坏死因子-α、白细胞计数、白细胞介素-6显著低于对照组,Hb水平显著高于对照组,差异具有统计学意义(P<0.05)。观察组总有效率96.67%(58/60)高于对照组的70.00%(42/60),差异具有统计学意义(P<0.05)。两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论奥美拉唑联合乌司他丁治疗消化道出血对病情的控制效果更好,且未增加不良反应。

Objective To analyze the efficacy of omeprazole combined with urinastatin in the treatment of gastrointestinal hemorrhage.Methods A total of 120 patients with gastrointestinal hemorrhage were randomly divided into control group and observation group,with 60 cases in each group.Patients in the control group were treated with omeprazole,and patients in the observation group were treated with omeprazole and urinastatin.Both groups were compared in terms of hemostasis time,abdominal pain relief time,hemoglobin(Hb)normalization time,blood pressure recovery time,negative time of stool occult blood test,serum inflammatory factor levels before and after treatment,clinical efficacy,and occurrence of adverse reactions.Results The hemostasis time(3.60±0.23)d,abdominal pain relief time(1.21±0.12)d,Hb normalization time(5.21±1.12)d,blood pressure recovery time(2.34±0.21)d,negative time of fecal occult blood test(4.13±0.21)d of the observation group were shorter than(4.65±0.45),(2.56±0.24),(7.24±1.21),(3.45±0.25),and(6.21±0.25)d of the control group,and the difference was statistically significant(P<0.05).After treatment,the high-sensitivity C-reactive protein,tumor necrosis factor-α,white blood cell count,and interleukin-6 of the two groups were significantly lower than those of this group before treatment,and the Hb was significantly higher than that of this group before treatment.All the differences were statistically significant(P<0.05).After treatment,the high-sensitivity C-reactive protein,tumor necrosis factor-α,white blood cell count,and interleukin-6 of the observation group were significantly lower than those of the control group,and the Hb was significantly higher than that of the control group.All the differences were statistically significant(P<0.05).The total effective rate 96.67%(58/60)in the observation group was higher than 70.00%(42/60)in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Omeprazole in combination with urinastatin for the treatment of gastrointestinal hemorrhage has better control effect on the condition,and does not increase the adverse reactions.