不同抗癫痫药物治疗癫痫的临床效果及对患儿认知功能的影响

Clinical effects of different antiepileptic drugs on epilepsy and their influences on cognitive function in children

目的探究卡马西平和左乙拉西坦治疗癫痫的临床效果及对患儿认知功能的影响。方法80例癫痫患儿作为研究对象,随机分为对照组及实验组,每组40例。对照组采用卡马西平治疗,实验组采用左乙拉西坦治疗。对比癫痫发作频率、认知功能评分、免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]水平及不良反应发生率。结果实验组癫痫发作频率(4.11±1.24)次/月低于对照组的(7.01±1.61)次/月,语言智商评分(106.44±10.40)分、操作智商评分(119.76±13.70)分、全量表智商评分(119.79±12.61)分高于对照组的(100.09±10.75)、(111.21±12.61)、(111.88±10.49)分,差异具有统计学意义(P<0.05)。实验组IgA、IgM、IgG水平分别为(1.69±0.51)、(1.30±0.56)、(11.31±1.41)g/L,高于对照组的(1.33±0.41)、(1.00±0.42)、(9.46±1.20)g/L,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论卡马西平和左乙拉西坦对癫痫均有一定疗效,特别是左乙拉西坦,不仅可以减少癫痫发作频率、改善认知功能,还可改善免疫能力,值得临床推广应用。

Objective To explore the clinical effects of carbamazepine and levetiracetam in the treatment of epilepsy and their influences on cognitive function in children.Methods 80 children with epilepsy were selected as study subjects and randomly divided into control group and experimental group,with 40 cases in each group.Patients in the control group were administered with carbamazepine,while patients in the experimental group were administered with levetiracetam.Epileptic seizure frequency,cognitive function score,levels of immune function indicators[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)]and incidence of adverse reactions were compared between the two groups.Results The frequency of epileptic seizures of the experimental group was(4.11±1.24)times/month,which was lower than(7.01±1.61)times/month of the control group;the experimental group had a verbal intelligence quotient score of(106.44±10.40)points,a performance intelligence quotient score of(119.76±13.70)points,a full-scale intelligence quotient score of(119.79±12.61)points,which were higher than(100.09±10.75),(111.21±12.61),(111.88±10.49)points of the control group,respectively;and the differences were statistically significant(P<0.05).The levels of IgA,IgM,IgG of the experimental group were(1.69±0.51),(1.30±0.56),(11.31±1.41)g/L,respectively,which were higher than(1.33±0.41),(1.00±0.42),(9.46±1.20)g/L of the control group,respectively,and the differences were statistically significant(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Carbamazepine and levetiracetam are both effective in the treatment of epilepsy.Levetiracetam can not only reduce the frequency of epileptic seizures,improve the cognitive function,but also improve the immunity.Thus,it is worthy of promotion in clinical application.