HBsAg阳性孕妇所分娩婴幼儿联合免疫后HBsAb应答研究进展

Research progress on HBsAb response after combined immunization in infants delivered by pregnant women with positive HBsAg

乙型肝炎病毒表面抗体(hepatitis B virus surface antibody,HBsAb)作为可中和乙型肝炎病毒(hepatitis B virus,HBV)的保护性抗体,在预防HBV感染中发挥重要作用。世界卫生组织指出HBsAb的保护力至少可持续30年,但对于母亲乙型肝炎病毒表面抗原(hepatitis B virus surface antigen,HBs Ag)阳性的高危儿童,临床观察到仍存在HBV再感染的风险。因此本文针对HBsAg阳性母亲所分娩婴幼儿在联合免疫后HBsAb的应答情况、免疫后HBV再感染情况及加强免疫的相关建议等研究进展进行综述,以期为乙肝疫苗的免疫效果评价及是否需要加强免疫等热点问题提供依据。

Hepatitis B virus surface antibody(HBsAb), as a protective antibody which neutralizes hepatitis B virus, plays an important role in the prevention of hepatitis B virus(HBV)infection. World Health Organization pointed out that the protection of HBsAb could last for at least 30 years, however, for children delivered by pregnant women with positive hepatitis B virus surface antigen(HBsAg), there was still a risk of HBV reinfection in clinic. Therefore,this article reviewed the research progress of HBsAb response after combined immunization,HBV reinfection after immunization and related suggestions for booster immunization in infants delivered by HBsAg-positive mothers in order to provide a basis for hot issues such as the evaluation of the immune effect of hepatitis B vaccine and the need for booster immunization.