摘要
Recently,two back-to-back studies(Slavik et al.1 and Holleufer et al.2)were published in Nature,identifying that cGAS-like receptors(cGLRs)extensively exist in Drosophila and act as nucleic acid sensors in the antiviral immune system.Furthermore,they also provided evidence demonstrating that cGLRs in Drosophila can sense dsRNA and produce 3′2′-cGAMP(cG[3′–5′]pA[2′–5′]p)as a second messenger that activates the Sting-dependent antiviral immune response.
基金
This work was supported by a special program from the Chinese National Natural Science Funds(U20A201393,31925013,32125016,82041009 and 31871405).
