摘要
Varying differentiation of myeloid cells is common in tumors,inflammation,autoimmune diseases,and metabolic diseases.The release of cytokines from myeloid cells is an important driving factor that leads to severe COVID-19 cases and subsequent death.This review briefly summarizes the results of single-cell sequencing of peripheral blood,lung tissue,and cerebrospinal fluid of COVID-19 patients and describes the differentiation trajectory of myeloid cells in patients.Moreover,we describe the function and mechanism of abnormal differentiation of myeloid cells to promote disease progression.Targeting myeloid cell-derived cytokines or checkpoints is essential in developing a combined therapeutic strategy for patients with severe COVID-19.
基金
This work was supported by grants from the National Natural Science Foundation of China(number U1804281,91942314,and 82103427)
the Emergency Prevention and Control of COVID-19 Project of Henan Province(grant number 201100310900)
the Major public welfare projects in Henan Province(201300310400)
Scientific Research Project of Epidemic Prevention and Control in Henan Province(211100310700).
