食源性沙门氏菌在人体胃肠道中耐受及致病机制研究进展

Research progress on tolerance and pathogenic mechanism of foodborne Salmonella spp.in human gastrointestinal tract

食源性沙门氏菌进入人体后将面临一系列不利于其生存的应激条件,适应这些条件并存活下来的沙门氏菌可通过自身毒力因子的作用侵袭人体细胞,最终导致人患病。该文围绕人体胃肠道中胃酸、胆汁和渗透压等胁迫因子,概述了沙门氏菌对体内逆境条件的耐受机制研究进展,并对其感染人体的过程及毒力因子进行了总结,以期为食源性沙门氏菌在人体胃肠道内各应激条件共同作用后的致病能力研究提供理论参考。

Foodborne Salmonella spp.will encounter a series of stress conditions that are not conducive to its survival after entering human gastrointestinal tract.Salmonella spp.that adapts to these conditions will cause human disease through the role of its own virulence factors.In this review,the tolerance mechanism of foodborne Salmonella spp.under the stress of gastric acid,bile and intestinal osmotic pressure is summarized,the process of its infection to the host and the mechanism of virulence factors are overviewed,in order to provide a theoretical reference for the research on the pathogenicity of foodborne Salmonella spp.after the combined action of various stress conditions in human gastrointestinal tract.