期刊文献+

儿童川崎病并发冠状动脉损害患儿C反应蛋白、血小板参数及羧化不全骨钙素的水平及其意义 被引量:4

Level and significance of C-reactive protein,platelet parameters and undercarboxylated osteocalcin in children with Kawasaki disease complicated with coronary artery lesions
下载PDF
导出
摘要 目的探讨川崎病并发冠状动脉损害(CALs)患儿血清C反应蛋白(CRP)、血小板计数(PLT)及羧化不全骨钙素(ucOC)水平及意义。方法选取2017年9月至2019年9月在我院治疗的川崎病患儿72例为观察组,同期选取健康体检儿童70例作为对照组。检测血清CRP、PLT及ucOC水平,采用超声心动图检查川崎病患儿CALs发生情况。结果观察组CRP和PLT明显高于对照组,ucOC明显低于对照组,差异有统计学意义(P<0.05);经超声心动图检查,有25例患儿伴有CALs;观察组伴CALs患儿CRP明显高于不伴CALs患儿,ucOC水平明显低于不伴CALs患儿,差异有统计学意义(P<0.05);观察组伴和不伴CALs患儿PLT比较差异无统计学意义(P>0.05);CRP、ucOC诊断川崎病患儿伴CALs的ROC曲线下面积分别为0.701和0.651(P<0.05),截断值分别为74.69 mg/L和12.36μg/L,灵敏性分别为48.00%和52.00%,特异性分别为87.23%和89.36%。结论川崎病并发CALs患儿CRP、PLT及ucOC水平升高,其中CRP和ucOC在诊断川崎病并发CALs中有一定应用价值。 Objective To investigate the serum C-reactive protein(CRP)level,platelet count(PLT)and undercarboxylated osteocalcin(ucOC)levels in children with Kawasaki disease complicated with coronary artery lesions(CALs)and its significance.Methods Totally 72 cases(observation group)of children with Kawasaki disease treated in our hospital from September 2017 to September 2019 were selected,and 70 healthy children receiving physical examination during the same period were selected as the control group.The serum CRP,PLT and ucOC levels were detected,and the occurrence of CALs in children with Kawasaki disease was examined by echocardiography.Results The CRP and PLT in the observation group were significantly higher than those in the control group(P<0.05),while ucOC was significantly lower than those in the control group(P<0.05).There were 25 children with CALs by echocardiography.In the observation group,CRP in children with CALs was significantly higher than that in children without CALs(P<0.05),while ucOC was significantly lower(P<0.05).There was no significant difference in PLT between children with and those without CALs in observation group(P>0.05).The area under ROC curve of CRP and ucOC in diagnosing Kawasaki disease with CALs was 0.701 and 0.651(P<0.05).Cut-off values were 74.69 mg/L and 12.36 g/L,the sensitivity was 48.00% and 52.00%,and specificity was 87.23% and 89.36%,respectively.Conclusion CRP,PLT and ucOC levels are increased in children with Kawasaki disease complicated with CALs,among which CRP and ucOC has certain application value in diagnosing Kawasaki disease complicated with CALs.
作者 李淑娟 梁宏 陈晓轶 LI Shujuan;LIANG Hong;CHEN Xiaoyi(Children's Hospital Affiliated to Zhengzhou University,Zhengzhou 450018,China)
出处 《中国中西医结合儿科学》 2021年第6期496-499,共4页 Chinese Pediatrics of Integrated Traditional and Western Medicine
基金 河南省医学科技攻关项目(2018020695)。
关键词 川崎病 冠状动脉损害 C反应蛋白 血小板计数 羧化不全骨钙素 儿童 Kawasaki disease Coronary artery lesion C-reactive protein Platelet count Undercarboxylated osteocalcin Children
  • 相关文献

参考文献8

二级参考文献27

  • 1陈芳,江杰,李卓颖,陈佳,田朗,李欣,伍志翔,黄利华,杨作成.谷胱甘肽过氧化物酶1基因多态性与川崎病的关联性分析[J].中国动脉硬化杂志,2015,23(3):290-294. 被引量:6
  • 2杜军保.川崎病的诊断与鉴别诊断[J].中国实用儿科杂志,2006,21(10):727-728. 被引量:45
  • 3Freeman AF,Shulman ST. Kawasaki disease: summary of theAmerican Heart Association guidelines[J]. Am Fam Physi-cian, 2006 ?74(7) : 1141-1148.
  • 4Newburger JW,Takahashi M, Gerber MA, et al. Diagnosis,treatment,and long term management of Kawasaki disease: astatement for health professionals from the Committee onRheumatic Fever,Endocarditis and Kawasaki Disease,Councilon Cadiovascular Disease in the Young?American Heart As-sociation[J]. Circulation,2004,110(17) :2747-2771.
  • 5Kawamura T,Wago M. Brain natriuretic peptide can be a use-ful biochemical marker for myocarditis in patients with Ka-wasaki disease[J]. Cardiol Young, 2002,12(2) : 153-158.
  • 6Ehara H, Kiyohara K, Izumisawa Y,et al. Early activationdoes not translate into effector differentiation of peripheralCD8T cells during the acute phase of Kawasaki disease[J].Cell Immunol?2010,265(1) :57-64.
  • 7Yu HR’Kuo HC,Sheen JM,et al. A unique plasma proteomicprofiling with imbalanced fibrinogen cascade in patients withKawasaki disease[J]. Pediatr Allergy Immunol,2009,20 (7):699-707.
  • 8Yu HR,Kuo HC,Huang EY,et al. Plasma clusterin levels in pre-dicting the occurrence of coronary artery lesions in patients withKawasaki disease[J]. Pediatr Cardiol,2010,31(8) : 1151-1156.
  • 9Huang MY, Gupta-Malhotra M, Huang JJ, et al. Acute-phasereactants and a supplemental diagnostic aid for Kawasaki dis-ease[J]. Pediatr Cardiol,2010,31(8) : 1209-1213.
  • 10Yu X, Hirono Kl’Ichida F, et al. Enhanced iNOS expression inleukocytes and circulating endothelial cells is associated withthe progression of coronary artery lesions in acute Kawasakidisease[J]. Pediatr Res,2004,55(4) :688-694.

共引文献85

同被引文献57

引证文献4

二级引证文献1

  • 1雷文娟,周奇,高琲,赵俊贤,刘辉,田敏,贾忠,王荣,虎亚光,魏玉辉,杨彦彪,张红梅,戴永利,周素琴,刘静,王法琴,雷晓燕,王建军,陶仲宾,杨轶男,王卫凯,徐瑞峰,马建丽,张海平,李丽亚,汤兴萍,王向东,李哲玮,邵婷玑,辛明彦,孟敏,葛斌.静脉注射免疫球蛋白治疗儿童川崎病的循证指南(2023)[J].兰州大学学报(医学版),2024,50(1):52-60.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部