摘要
Eukaryotic transcription begins with the assembly of general transcription factors(GTFs)including TFIID,IIA,IIB,IIE,IIF,and IIH,which help Pol II to engage with promoters.The binding of TATA-box binding protein(TBP)to DNA,which causes the bending of TATA sequence,is the first step of the preinitiation complex(PIC)formation,and TBP is essential for almost all gene expression.TBP is an integral part of the TFIID complex which includes 13 other TBP-associated factors(TAFs)and can be separated into 3 submodules(TFIID-A,-B and-C)(Chen et al.,2021a).
