肝脏糖脂代谢研究的趋势变化分析与展望

Developmental trend analysis and perspectives on researches related to hepatic glucose and lipid metabolism

糖脂代谢稳态平衡是多因素、多器官协调互作的结果,是维持人类健康的基本要素之一。肝脏作为最主要的代谢器官,在机体糖脂代谢稳态调控中发挥至关重要的作用。随着研究的不断深入,肝脏糖脂代谢相关的论文数量日益增长,给快速了解肝脏糖脂代谢领域的研究热点和发展趋势带来了挑战。为解决这一问题,本研究开发了一种信息分析方法,通过对肝脏糖脂代谢领域研究论文涉及的《医学主题词表》(Medical Subject Headings, MeSH)中的词条和相关高通量研究数据的收集与解析,对肝脏糖脂代谢领域近30年来的研究现状、研究手段和研究热点变化等因素进行了系统分析。结果显示,本世纪以来,肝脏糖脂代谢研究相关的论文数量,尤其是中国学者发表的论文数量快速提升,论文的篇均作者数量和篇均作者单位数量也显著增加,并且这一数量变化与论文的影响力之间存在一定的正相关。各种高通量方法逐渐成为肝脏糖脂代谢遗传学相关研究的主要手段,过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptors, PPARs)、固醇调节元件结合蛋白(sterol regulatory element binding proteins, SREBPs)、核因子E2相关因子2 (NF-E2-related factor 2, Nrf2)等转录因子成为肝脏糖脂代谢研究的新兴热点。这些结果系统展示了肝脏糖脂代谢研究的关注重点和变化趋势,本文所开发的方法也可被应用于对其他领域进行类似的研究热点分析。

The balance of glucose and lipid metabolism is a coordinated result of multiple factors and organs, and is one of the fundamental requirements for the maintenance of human health. As the most important organ for human metabolism, liver plays a key role in regulating glucose and lipid metabolism. With the advances of researches, the number of publications related to hepatic glucose and lipid metabolism has increased rapidly, which posed a challenge for grasping the hot research topics and developmental trends of hepatic glucose and lipid metabolism in a short time. To solve such problem, we developed an information analysis method, which systematically analyzes the research status, research techniques, and hot research topics of the hepatic glucose and lipid metabolism research field through Medical Subject Headings(MeSH) of related papers and high-throughput experimental data. The results showed that the number of publications related to hepatic glucose and lipid metabolism, especially publications by Chinese scholars, has increased dramatically in this century, along with the remarkable increment of the numbers of authors and affiliations per paper. Such increment is in part positively correlated with the impact of publications. Nowadays, various types of high-throughput experimental techniques have become the main research methods for genetic studies of hepatic glucose and lipid metabolism. Transcription factors,such as peroxisome proliferator-activated receptors(PPARs), sterol regulatory element binding proteins(SREBPs), and NF-E2-related factor 2(Nrf2), have become the new research hotspots. These results systematically showed the current focuses and developmental trends of hepatic glucose and lipid metabolism research, and the data analysis method developed in this work can also be applied to other research fields.