亳州市地区COVID-19临床资料特征学及相关性分析

Characteristics and Correlation Analysis of COVID-19 Clinical Data in Bozhou City

目的回顾性分析亳州市地区新型冠状病毒性肺炎(COVID-19)确诊患者临床资料的一般特征,并探讨各指标之间的相关性,为疫情防治工作提供参考。方法收集我院新冠肺炎确诊患者临床信息及相关资料并进行回顾性分析,对各指标进行相互性的相关分析,探讨各指标之间相关性。结果共收集病例102例,结果提示临床检验指标正常例数较多,其中C-反应蛋白(CRP)、凝血酶时间(TT)、乳酸脱氢酶(LDH)、血浆纤维蛋白原(Fib)升高人数较多,白细胞计数(WBC)、Na^(+)降低人数较多,淋巴细胞百分比(LY%)升高人数和降低人数相当,正常病例数居多。其中58例确诊至转阴时间集中在7~13天,1~6天12例、14~20天30例、20天以上者2例。收集患者以症状为依据进行分组,组间各计量资料分别进行两两比较提示多组间存在统计学差异。发热组与无症状组间存在差异性的指标数较多,余有症状组与无症状组之间亦存在较多差异性指标。对各指标分别进行两两之间Pearson相关性分析,提示CRP、LY%与较多指标存在相关性。生化指标两两之间存在相关性,生化指标与凝血及D-二聚体(D-D)之间存在相关性。凝血+D-二聚体指标中以TT、PT、Fib具有相关性的指标较多,以WBC、LY%、生化性指标为主。收集患者一般性临床资料包括身体质量指数(BMI)、年龄、住院时长、花费,其中花费及年龄与临床计量资料间具有较多数的相关性指标。结论亳州市地区COVID-19102例患者中多数临床指标正常,具有代表性的临床指标为LY%、CRP、LDH、TT、Fib等。无症状病例组与有症状病例组间临床指标差异性较大,各临床指标间存在潜在相关性。

Objective To retrospectively analyze the general characteristics of clinical data of patients diagnosed with COVID-19 in Bo zhou city,and to explore the correlation between each index,so as to provide reference for the prevention and treatment of epidemic situation.Methods The clinical information and related data of the patients diagnosed were collected and analyzed retrospectively,and the correlation of each index is analyzed and the correlation between each index is discussed.Results A total of 102 cases were collected,the results showed that the number of normal cases was more,including C-reactive protein(CRP),thrombin time(TT),lactate dehydrogenase(LDH),plasma fibrinogen(Fib),white blood cell count(WBC),Na^(+)decreased,lymphocyte percentage(LY%)increased and decreased,the number of normal cases was the majority.Among them,58 cases were diagnosed in 7~13 days,12 in 1~6 days,30 in 14~20 days,and more than 20 days was 2.The patients were grouped according to symptoms,and the data for each group were compared with each other,which indicated that there was a statistical difference between the two groups.There were many indexes of difference between fever group and asymptomatic group,and there were many indexes of difference between symptomatic group and asymptomatic group.Correlation analysis of each index Pearson pairwise is carried out,which indicates that CRP、LY%has correlation with more indexes.There was considerable correlation between biochemical indexes and coagulation and D-dimer(D-D).There are many TT、PT、Fib related indexes in coagulation D-dimer,mainly WBC、LY%biochemical indexes.Collect general clinical data of patients including body mass index(BMI),age,length of stay,cost,in which the cost and age and clinical measurement data is under a large number of correlation indicators.Results COVID-19 in Bozhou City Among 102 patients,most of the clinical indexes were normal,and clinical representative indexes were LY%、CRP、LDH、TT、Fib.There is a great difference between asymptomatic and symptomatic groups,and there is a potential correlation among clinical indicators.