哺乳期急性乳腺炎患者血小板水平的变化及临床意义

Changes and clinical significance of platelet level in patients with acute mastitis during lactation

目的研究血小板(PLT)水平在哺乳期急性乳腺炎中的变化及临床意义。方法选取2016年2月-2018年4月我院收治的哺乳期急性乳腺炎患者54例与同期来院体检的哺乳期健康成年女性54例,分别作为观察组与对照组。检测入院时、入院3天后观察组及对照组PLT数量、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)、大血小板比率(P-LCR)的水平。结果两组受试者入院时PLT、MPV、PDW、PCT水平比较差异均无统计学意义(P>0.05);观察组入院3天后PLT、MPV、PDW、PCT水平明显高于本组入院时,比较差异有统计学意义(P<0.05);对照组受试者入院时、入院3天后PLT、MPV、PDW、PCT水平比较差异均无统计学意义(P>0.05);两组受试者入院时、入院3天后P-LCR水平比较差异均无统计学意义(P>0.05)。结论PLT水平的变化可作为哺乳期急性乳腺炎患者实验室检查指标之一,对患者后续治疗也具有一定临床意义,临床应如何进行抗血小板治疗需进一步研究。

Objective To study the changes and clinical significance of platelet(PLT)levels in breast-feeding acute mastitis.Methods 54 breast-feeding patients with acute mastitis admitted to our hospital from February 2016 to April 2018 and 54 breast-feeding healthy adult women who came to the hospital for physical examination during the same period were selected as the observation group and the control group,respectively.The levels of PLT number,mean platelet volume(MPV),platelet distribution width(PDW),platelet packed product(PCT),and large platelet ratio(P-LCR)were detected at the time of admission and 3 days after admission.Results There was no significant difference in the levels of PLT,MPV,PLT,and MPV between the two groups of subjects upon admission(P>0.05);the levels of PLT,MPV,PDW,and PCT in the observation group were significantly higher than those in the group at admission 3 days after admission.The difference was statistically significant(P<0.05);there was no significant difference in the levels of PLT,MPV,PDW,and PCT when the subjects in the control group were admitted to the hospital and 3 days after admission(P>0.05);the two groups of subjects were admitted to the hospital There was no statistically significant difference in P-LCR levels at time and 3 days after admission(P>0.05).Conclusion The change of PLT level can be used as one of the laboratory examination indexes of patients with acute mastitis during lactation,and it also has certain clinical significance for the follow-up treatment of patients.The clinical application of antiplatelet therapy needs further research.