急性脑梗死患者血清流星素和白介素6的相关性研究

Correlation between serum Metrnl and interleukin-6 in patients with acute cerebral infarction

目的流星素(meteorin-like,Metrnl)作为一种新型脂肪因子在动脉粥样硬化和炎症反应中发挥一定的作用,本研究旨在探究血清Metrnl水平和急性脑梗死及炎症因子的相关性。方法选取确诊急性脑梗死的139例患者为急性脑梗死组(ACI组),选取同时期130例正常人为健康对照组(N-ACI组),通过酶联免疫吸附法(ELISA)测定受试者血清Metrnl浓度,同时检测了常见的卒中危险因素,并通过统计学方法比较血清Metrnl水平和急性脑梗死及常见危险因素的相关性。结果 ACI组的血清Metrnl水平低于N-ACI组(P <0.001),在调整混杂因素后差异仍然显著,提示低Metrnl水平和急性脑梗死显著相关。在急性脑梗死组中血清Metrnl水平和身体质量指数(BMI)、同型半胱氨酸(HCY)、低密度脂蛋白、血浆致动脉硬化指数(AIP)呈负相关;Metrnl和炎症标志物超敏C-反应蛋白(HsCRP)及白介素6(IL-6)呈负相关,进行回归分析后发现Metrnl是急性脑梗死的保护性因素。结论血清Metrnl水平与急性脑梗死的发生显著相关,同时血清Metrnl水平和炎症因子IL-6呈负相关,Metrnl作为急性脑梗死的新型生物标志物可能成为新的诊断及治疗靶点。

Objective As a new adipokine,Metrnl is closely related to atherosclerosis and inflammatory response. This study aims to explore the correlation between serum Metrnl level and acute cerebral infarction and inflammatory factors.Methods 139 patients with acute ischemic stroke were selected as ACI group,and 130 people with physical examination were selected as N-ACI group. The serum Metrnl level was measured by ELISA,and the common risk factors of stroke were detected. The correlation between serum Metrnl level and acute cerebral infarction and common risk factors was compared by statistical methods. Results The level of serum Metrnl in patients with ACI was lower than that in the control group( P < 0. 001).After adjusting for confounding factors,the difference was still significant,indicating that low level of Metrnl was significantly correlated with acute cerebral infarction. In the acute cerebral infarction group,the level of serum Metrnl was negatively correlated with BMI,HCY,LDL,AIP,and was negatively correlated with inflammatory markers Hs-CRP and IL-6. Regression analysis showed that Metrnl was a protective factor for acute cerebral infarction. Conclusion The level of serum Metrnl is significantly correlated with the occurrence of acute cerebral infarction. At the same time,the level of serum Metrnl is negatively correlated with inflammatory factor IL-6. As a new biomarker of acute cerebral infarction,Metrnl may become a new diagnostic and therapeutic target.