高血压合并糖尿病患者左心室肥大与血压变异性指数的相关性分析

Analysis of the correlation between left ventricular hypertrophy and blood pressure variability index in patients with hypertension complicated with diabetes

目的研究高血压合并糖尿病患者左心室肥大与血压变异性(BPV)指数的相关性。方法纳入高血压合并糖尿病患者120例,并根据患者的临床确诊资料信息及心电图资料将患者分为左心室肥大(LVH)组和非LVH组,比较两组的BPV相关指数,Logistic回归分析患者左心室肥大的相关危险因素,Pearson相关分析左心室质量指数(LVMI)与BPV各指标之间的相关性。结果高血压合并糖尿病LVH组患者较非LVH组患者的白天收缩压变异系数(dSBPCV)、白天舒张压变异系数(dDBPCV)、24 h收缩压变异系数(24hSBPCV)、24 h舒张压变异系数(24hDBPCV)均显著上升(P<0.05);Logistic回归分析结果提示dSBPCV、dDBPCV、24hDPBCV、24hSBPCV水平的上升是高血压合并糖尿病患者左心室肥大的相关危险因素(OR>1,P<0.05);Pearson相关分析结果提示:LVMI与24hSBPCV、24hDBPCV以及dSBPCV、dDBPCV均呈正相关(r分别为0.345、0.412、0.387、0.441,P<0.05)。结论高血压合并糖尿病患者BPV对于患者左心室肥大有一定的影响,临床可将BPV作为高血压合并糖尿病患者靶器官受损的预测因素,控制BPV对于早期预防以及治疗患者左心室肥大均有一定的临床价值。

Aim To study correlation between left ventricular hypertrophy(LVH)and index of blood pressure variability(BPV)in patients with hypertension complicated with diabetes mellitus.Methods 120 hypertension patients combined with diabetes mellitus were included,and divided into LVH group and non-LVH group according to their clinical confirmed information and electrocardiographic data.BPV-related indices were compared between the two groups,Logistic regression was used to analyze the risk associated with LVH in patients.Pearson correlation analysis was used to analyze the correlation between left ventricular mass index(LVMI)and BPV.Results In patients with hypertension and diabetes,daytime systolic blood pressure variability coefficient(dSBPCV),daytime diastolic blood pressure variability coefficient(dDBPCV),24 h systolic blood pressure variaility coefficient(24hSBPCV),and 24 h diastolic blood pressure variability coefficient(24hDBPCV)in LVH group were significantly higher than those in non-LVH group(P<0.05).Logistic regression analysis showed that the increase of dSBPCV,dDBPCV,24hDBPCV and 24hSBPCV were related risk factors for LVH in hypertensive patients with diabetes mellitus(OR>1,P<0.05).Pearson correlation analysis showed that LVMI was positively correlated with 24hSBPCV,24hDBPCV,dSBPCV and dDBPCV(r=0.345,0.412,0.387 and 0.441,P<0.05).Conclusions BPV in hypertensive patients with diabetes mellitus has a certain effect on left ventricular hypertrophy.BPV can be used as a predictor of target organ damage in hypertensive patients with diabetes mellitus.BPV control has a certain clinical value for early prevention and treatment of left ventricular hypertrophy.