PD-1阻断剂所致皮肤不良反应分析及文献回顾

PD-1 blockade therapy induced skin irAEs:cases report and literature review

抗程序细胞死亡蛋白1及配体阻断剂为代表的免疫治疗在肿瘤治疗中取得了突破性的进展,皮肤不良反应是最常见的免疫相关不良反应(irAEs)。本文报道临床中诊治的一组免疫相关不良反应,共4例,分别为湿疹、多形红斑、TEN、嗜酸细胞增多性皮炎,并回顾分析在Pubmed数据库检索2015年至今发表的PD-1/PD-L1免疫治疗导致皮肤不良反应的病例报道,包括患者年龄、性别、致皮肤irAEs的药物、皮肤irAEs类型等。以期提高对肿瘤免疫治疗过程中皮肤不良反应的关注,及时救治危及生命的皮肤不良反应,帮助改善肿瘤患者生存质量和预后。

PD-1/PD-L1 blockade therapy is a representative immunotherapy that shows a major breakthrough in cancer therapy and dermatologic reactions are the most prevalent immune-related adverse events(irAEs).We reported 4 cases of different skin irAEs,including eczema,erythema multiforme,TEN,eosinophilic dermatitis.And the studies of dermatologic reactions induced by PD-1/PD-L1 blockade from Pubmed since 2015 were respectively analyzed,including sex,age,drug and lesion type,etc.In order to improve the attention of irAEs manifested as skin disease,to timely treat the patient with life-threatening adverse reactions,and to help improve the quality of life and prognosis of tumor patients.