甲母质瘤一例并文献复习

Onychomatricoma:a case report and literature review

报道一例甲母质瘤并对相关文献进行复习。患者,男,54岁。右手食指指甲增厚、变黄10年。组织病理检查:甲板显著增厚,甲母质细胞V形增生,底端呈条索状伸向真皮,上端呈乳头瘤样伸向甲板,上覆嗜酸性角质增生带,部分乳头瘤顶端见渗出结痂。真皮浅层梭形细胞增生,排列杂乱,间有散在肥大细胞,深部纤维及纤维细胞增生,排列与表皮平行。免疫组化染色:梭形细胞CD34阳性,S-100阴性,FⅩⅢa阴性,CD68阴性,CK7阴性。诊断:甲母质瘤。手术切除肿瘤后随访10个月无复发。

A case of onychomatricoma was reported and related literature was reviewed.A 54-year-old male presented with 10-year history of thickening and xanthonychia of nail plate on the right second fingernail.Histopathological examination showed the nail plate thickening,proximal matrix cells V-shaped proliferation,distal zone papillary projection along nail plate covered by eosinophilic keratogenous zone,exudation and crusting on part of tip of papilloma,spindle cells accumulated with scattered mast cells in upper dermis,in deep dermis fibres and fibrocytes proliferated that arranged parallel to the epidermis.Immunohistochemistry showed CD34 positive in spindle cells,S-100,F XIIIa,CD68,and CK7 negative.The diagnosis of onychomatricoma was made.The patient was treated with complete surgical excision of the tumor with no recurrence after 10 months follow-up.