晚期肺癌患者应用PD-1抑制剂致银屑病样药疹一例并文献复习

Psoriasiform eruption in patients with advanced lung cancer treated with a PD-1 inhibitor (tirelizumab):a case report and literature review

报道1例75岁男性晚期肺癌患者应用PD-1抑制剂(替雷利珠单抗)免疫治疗后引起银屑病样药疹并进行文献复习。患者在替雷利珠单抗治疗1周后出现由甲床开始,逐渐累及四肢、躯干的鳞屑性皮疹,伴有瘙痒及双下肢肿胀。皮损组织病理未见银屑病特征性表现。经治疗后患者无新发皮疹,原有皮疹明显消退,鳞屑脱落。诊断:银屑病样药疹,给予糖皮质激素等治疗后,患者逐渐好转。

We reported a psoriasiform eruption after immunotherapy with a PD-1 inhibitor(tirelizumab) in a 75-year-old man with advanced lung cancer and reviewed the literature.The patient presented with scaly rash on the nail bed,then spread to the whole body,with itching and swelling of both legs after one week of treated with tirelizumab.Histopathology of the lesion showed no characteristic features of psoriasis.The diagnosis of psoriasiform eruption was made and,then the patient treated with glucocorticoid,the patient gradually improved.