中国拉萨藏族人群饮酒行为与高尿酸血症的关联--基于倾向性得分加权方法

Association between drinking behavior and hyperuricemia of the Zang people in Lhasa of China:Based on the weighting method of propensity score

[目的]分析我国拉萨藏族人群饮酒行为与高尿酸血症(HUA)的关联关系,探寻潜在高危人群,为后续开展拉萨藏族地区健康促进、健康干预策略提供理论依据。[方法]依托于国家重点研发计划“西南区域自然人群队列”,选取其中拉萨藏族人群作为研究对象。在倾向性评分的理论体系下,选用逆概率加权法对每个研究对象进行加权,加权后数据集进行平衡性检验,再进一步针对加权后数据集采用单因素分析方法比较不同饮酒状况下高尿酸血症检出率的差异。加权分析结果与传统多因素分析、匹配法倾向评分匹配分析进行比较。[结果]调查人群HUA阳性检出率为22.68%。经倾向性评分加权后单因素回归发现,经常饮酒行为与高尿酸血症正相关,OR=3.89(95%CI=3.57~4.24)。此外,使用加权前的多因素Logistic回归、匹配法计算经常饮酒行为与高尿酸血症的关联程度,OR分别为2.99(95%CI:2.28~3.93)和2.73(95%CI:1.88~3.95)。[结论]拉萨人群地区高尿酸血症的检出率较高,经常饮酒是高尿酸血症的危险因素,应该针对饮酒这一危险因素开展降低高尿酸血症的健康促进、干预活动。重点干预人群的选择还需要大量研究来补充证实。

Objective To analyze the relationship between drinking behavior and hyperuricemia(HUA)among the Zang people in Lhasa and explore potential high-risk groups so as to provide theoretical basis for follow-up work of health promotion and health intervention strategies in Lhasa of Xizang areas.Methods It relied on national key research and development plan of“Southwestern Region Natural Population Cohort”,in which the Zang people in Lhasa were selected as the research object.Under the theoretical system of propensity score,the inverse probability weighting method was used to weight for each research object,and balance test for the weighted data set,and aimed at the weighted data set,the single factor analysis method was used to compare the difference of hyperuricemia detection rate under different drinking conditions.The results of weighted analysis were compared with traditional multivariate analysis and matching method.Results HUA positive rate of research group was 22.68%.After weighted by propensity score,the single factor regression showed that frequent drinking was positively associated with HUA,OR=3.89(95%CI=3.57-4.24).In addition.The multi-factor logistic regression before weighting and matching method calculated for correlation degree between frequent drinking behavior and hyperuricemia which OR was 2.99(95%CI:2.28-3.93)and 2.73(95%CI:1.88-3.95)respectively.Conclusions The detection rate of hyperuricemia is high in Lhasa.Frequent drinking is risk factor of hyperuricemia.Health promotion and intervention activities should be carried out to reduce hyperuricemia.However,the selection of key intervention groups needs more studies to supplement and confirm.