替米沙坦治疗轻中度高血压并糖尿病疗效及安全性观察

Observation on Efficacy and Safety of Telmisartan in Treatment of Mild to Moderate Hypertension Complicated with Diabetes Mellitus

目的:分析替米沙坦治疗轻中度高血压(HBP)并糖尿病(DM)的效果与安全性。方法:将2018年10月-2020年10月收治的105例患者,分为两组,试验组53例,对照组52例。试验组给予替米沙坦治疗,对照组给予氨氯地平治疗,在安全性和效果之间进行比较。结果:有效率方面试验组优于对照组,结果有统计学意义(P<0.05)。试验组治疗后空腹血糖(FPG)及糖化血红蛋白(HbA1c)水平、空腹胰岛素(FINS)优于对照组,差异有统计学意义(P<0.05)。血压及不良反应方面均不理想,无统计学意义(P>0.05)。试验组治疗后血肌酐(Cr)、尿素氮(BUN)及尿蛋白定量等肾功能指标水平均低于对照组,差异有统计学意义(P<0.05)。结论:采取替米沙坦治疗轻中度HBP+DM,能够改善血压、血糖水平,且不会增加用药风险。

Objective:To analyze the efficacy and safety of telmisartan in the treatment of mild to moderate hypertension(HBP)complicated with diabetes mellitus(DM).Methods:One hundred and five patients who were received and treated between October 2018 and October 2020 were divided into two groups:experimental group(n=53)and control group(n=52).The experimental group was treated with telmisartan;The control group was treated with amlodipine.The safety and effectiveness in two groups were compared.Results:The effective rate in the experimental group was higher,with statistically significant results(P<0.05).After treatment,the levels of fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c)and fasting insulin(FINS)of the experimental group were higher than those of the control group,and the results were statistically significant(P<0.05).There was no statistical significance in blood pressure and adverse reactions,which were not satisfactory(P>0.05).The levels of renal function indexes such as serum creatinine(Cr),blood urea nitrogen(BUN)and urine protein in experimental group were lower than those in control group after treatment,with statistical significance(P<0.05).Conclusion:Telmisartan treatment of mild to moderate HBP+DM can improve blood pressure and blood glucose levels without increasing the risk of medication.