综合干预对肥胖男性青少年血管生成素样蛋白2和血管内皮功能的影响

Effect of comprehensive intervention on ANGPTL2 and vascular endothelial function in obese male adolescents

目的观察运动结合饮食控制的综合干预方案对肥胖男性青少年血管生成素样蛋白2(angiopoietin-likeprotem 2,ANGPTL2)和血管内皮功能的影响,为运动降低肥胖男性青少年心血管疾病风险提供理论依据。方法选取42名肥胖男性青少年和10名健康男性青少年分别为实验组和对照组,对实验组青少年开展6周运动结合饮食控制的综合干预,测定干预前后身体形态和血压、糖脂代谢、炎症水平和血管内皮功能的变化。结果6周综合干预后,实验组青少年的体重、体质量指数(BMI)、腰围、腰臀比、收缩压、舒张压指标均降低(P值均<0.05);总胆固醇、三酰甘油、低密度脂蛋白胆固醇血脂水平均降低(P值均<0.05);肿瘤坏死因子α、ANGPTL2炎症水平均降低(P值均<0.05);反应性充血指数(RHI)、一氧化氮/内皮素-1(NO/ET-1)、一氧化氮、动脉粥样硬化指数(AI)血管内皮功能显著改善(P值均<0.05)。综合干预前后,肥胖男性青少年的ANGPTL2变化值与体重(r=0.37)、BMI(r=0.45)、RHI(r=-0.46)、NO/ET-1(r=-0.41)、NO(r=-0.45)、AI(r=0.33)的变化值显著相关(P值均<0.05)。结论综合干预能有效改善肥胖男性青少年的身体形态、血脂水平和血管内皮功能,降低ANGPTL2水平。ANGPTL2可能参与了综合干预对肥胖男性青少年血管内皮功能的改善过程。

Objective To investigate the effect of a comprehensive exercise intervention program combined with diet control on ANGPTL2 and vascular endothelial function in obese male adolescents, and to provide theoretual basis for exercise to reduce the risk of cardiovascular disease in obese male adolescents. Methods Forty-two obese male adolescents and 10 healthy male adolescents were selected, a comprehensive intervention of 6 weeks of exercise combined with diet control was carried out on obese male adolescents, and changes in morphological function, glucose and lipid metabolism, inflammation level and vascular endothelial function were measured before and after the intervention. Results After 6 weeks of comprehensive intervention, the morphological and functional indicators of obese adolescents were significantly reduced: weight, BMI, waist circumference, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure(P<0.05);blood lipid levels significantly decreased, including TC, TG and LDL-C(P<0.05);inflammation levels significantly decreased, including TNF-α and ANGPTL2(P<0.05);Vascular endothelial function significantly improved: RHI, NO/ET-1, NO, AI(P<0.05). Before and after 6 weeks of comprehensive intervention, the ANGPTL2 of obese adolescents was significantly correlated with weight(r=0.37), BMI(r=0.45), RHI(r=-0.46), NO/ET-1(r=-0.41), NO(r=-0.45), and AI(r=0.33)(P<0.05). Conclusion The comprehensive intervention can effectively improve the morphological function, blood lipid level and vascular endothelial function of obese male adolescents, and reduce the circulating level of ANGPTL2. ANGPTL2 may be involved in the process of comprehensive intervention to improve the vascular endothelial function of obese adolescents.