呼吸道病毒感染中宿主限制因子研究进展

Research progress on host restriction factors of respiratory viruses

呼吸道病毒可引起多种严重的呼吸道感染以及呼吸道外组织器官病变,给人类健康造成重大威胁。病毒依赖于宿主细胞内在机制维持自身的复制和存活,而宿主也存在多种限制因子抑制病毒入侵、基因组转录、复制、组装和释放等环节阻断病毒感染。现将常见呼吸道病毒宿主限制因子的抗病毒作用及其相关机制的研究进展进行综述。

Respiratory viruses can cause a variety of serious respiratory infections and diseases of tissues and organs outside the respiratory tract,raising a potentially severe threat to the society.Virus replication and survival rely on the internal mechanism of host cells,and the latter also produce a variety of restriction factors that target viral invasion,genome transcription and replication,and assembly and release to block viral infection.Herein,this study reviewed the research progress of the antiviral effects of the host restriction factors of common respiratory viruses and their underlying mechanisms.