内皮素-1基因Lys198Asn多态性与缺血性卒中

Endothelin-1 gene Lys198Asn polymorphism and ischemic stroke

内皮素(endothelin,ET)是由内皮细胞产生的一种强效血管收缩肽,与血管内皮功能障碍和心脑血管病密切相关。近年来的研究显示,ET-1基因Lys198Asn多态性可作为脑血管病的一种新型生物标志物。文章综述了该基因多态性与缺血性卒中易感性之间关系的研究进展并探讨其临床意义。

Endothelin(ET)is a potent vasoconstrictor peptide produced by endothelial cells,which is closely associated with vascular endothelial dysfunction and cardio-cerebrovascular diseases.Recent studies have shown that ET-1 gene Lys198Asn polymorphism can be used as a new biomarker of cerebrovascular diseases.This article reviews the research progress on the relationship between the gene polymorphism and susceptibility to ischemic stroke,and discusses its clinical significance.