多模式干预对帕瑞昔布临床应用合理性的影响

Influence of multi-modal intervention on the rationality of parecoxib in clinical application

目的探讨处方前置审核、药学干预和行政干预组成的多模式干预对帕瑞昔布临床应用合理性的影响。方法根据建立的帕瑞昔布药物利用评价(DUE)标准进行回顾性研究,采用属性层次模型(AHM)法对干预前随机抽取的200例帕瑞昔布归档病例的合理性进行评价。对不合理问题采取多模式干预,采用AHM法对干预后随机抽取的200例帕瑞昔布归档病例合理性进行评价。对干预前后病例的合理性进行分析,进而对多模式干预的效果进行讨论。结果干预前病例平均得分(75.17±17.28)分,干预后病例平均得分(79.41±15.69)分,干预前后病例得分经t检验,差异具有统计学意义(P<0.05)。结论多模式干预可利用各自的优点,相互协作,在促进帕瑞昔布的临床合理应用上具有一定的作用,特别是禁忌、疗效及联合用药。

AIM To explore the effect of multi-modal intervention composed of pre-prescription review,pharmaceutical intervention and administrative intervention on the rationality of parecoxib in clinical application.METHODS A retrospective study was conducted based on the established parecoxib drug use evaluation(DUE)criteria,and the rationality evaluation of 200 archived cases of parecoxib selected randomly before the intervention was evaluated by analytic hierarchical model(AHM)method.Unreasonable problems were intervened by multi-modal intervention,then the rationality of 200 cases of parecoxib randomly selected after the intervention was evaluated by AHM method.Analyze the rationality of cases before and after intervention,and then discuss the effects of multi-modal intervention.RESULTS The average score before the intervention was(75.17±17.28).After the intervention,the average score was(79.41±15.69).The medical record score before and after intervention were tested by t test(P<0.05),which was statistically significant.CONCLUSION Multi-modal intervention can take advantage of their respective advantages and cooperate with each other to play a certain role in promoting the rational clinical application of parecoxib,especially in contraindication,efficacy and combination medication.