^(90)Sr敷贴治疗头发部位婴幼儿血管瘤的疗效及治疗对发量的影响

Therapeutic effect of ^(90)Sr application on infantile hemangioma in hair area and its influence on hair volume

目的探讨^(90)Sr敷贴治疗头发部位浅表型婴幼儿血管瘤的临床疗效及该疗法对瘤体处发量的影响。方法纳入2018年2月至2019年10月广西医科大学第一附属医院收治的136例(男55例,女81例,年龄1~30个月)头发部位婴幼儿血管瘤患儿(136处病灶),根据瘤体部位头发浓密度分为3组:A组[63例,年龄3(2,6)个月,男/女=27/36]瘤体处头发与周围头发一样浓密;B组[40例,年龄3(2,5)个月,男/女=17/23]瘤体处头发较周围稀少;C组[33例,年龄3(2,6)个月,男/女=11/22]瘤体处无头发生长。均采用^(90)Sr敷贴治疗,每疗程总吸收剂量为10~30 Gy,分8次完成。疗程结束后3~4个月评估3组疗效、不良反应,并根据治疗后瘤体处头发浓密度分为生长茂盛、生长良好、不生长3个等级。疗效不满意者行第2疗程治疗。组间比较行Kruskal-Wallis秩和检验或χ^(2)检验。结果A组、B组和C组年龄(H=0.01)、性别构成(χ^(2)=0.92)差异无统计学意义(均P>0.05)。3组2个疗程总痊愈(病变完全消失,无功能障碍)率分别为88.9%(56/63)、95.0%(38/40)和93.9%(31/33),不良反应发生率分别为6.3%(4/63)、7.5%(3/40)和9.1%(3/33),差异均无统计学意义(χ^(2)值:1.49、0.24,均P>0.05)。治疗后3~4个月,A、B组患儿瘤体处头发均生长茂盛,C组28例患儿生长茂盛,5例患儿生长良好,无患儿出现不生长。结论^(90)Sr敷贴治疗头发部位的小面积浅表型婴幼儿血管瘤疗效好,治疗后瘤体处发量基本恢复正常。该方法在临床上具有推广应用价值。

Objective To investigate the clinical effect of ^(90)Sr application on superficial hemangioma in hair area and its effect on the volume of hair.Methods A total of 136 pediatric patients(55 males,81 females,1-30 months old;136 lesions)with head hemangioma in the First Affiliated Hospital of Guangxi Medical University between February 2018 and October 2019 were enrolled.They were divided into 3 groups according to the hair density of tumor sites.Group A(n=63,3(2,6)months old,male/female=27/36):the hair in tumor sites was as thick as the surrounding hair.Group B(n=40,3(2,5)months old,male/female=17/23):the hair in tumor sites was thinner than the surrounding area.Group C(n=33,3(2,6)months old,male/female=11/22):there was no hair growth in the tumor sites.All groups were treated with ^(90)Sr application,and the total absorbed dose of each course was 10-30 Gy,which was divided into 8 times.Three to four months after the treatment,the efficacy and adverse reactions were evaluated and the volume of hair was divided into 3 grades according to the hair density of the tumor sites:flourishing,good growth and no growth.If the clinical effect was unsatisfied,a second course of treatment was conducted.Kruskal-Wallis rank sum test orχ^(2) test was used for data analysis.Results The differences of age(H=0.01),gender(χ^(2)=0.92)among group A,group B and group C were not significant(both P>0.05).The total recovery rates of 3 groups after two-course treatment were 88.9%(56/63),95.0%(38/40)and 93.9%(31/33)respectively(χ^(2)=1.49,P>0.05).Besides,the incidences of adverse reactions were 6.3%(4/63),7.5%(3/40)and 9.1%(3/33)respectively(χ^(2)=0.24,P>0.05).Three to four months after treatment,the hair on tumor sites in group A and B was rated as flourishing,28 children in group C were rated as flourishing,5 children were rated as good growth,and none of the children showed no growth.Conclusions The ^(90)Sr application has a good treatment effect on the small superficial hemangioma in the hair area of infants,and the amount of hair in the affected area can be restored to normal after treatment.This treatment is worthy of clinical application.