流式细胞术在造血和淋巴组织肿瘤诊疗中应用的思考

Thinking of flow cytometry in the diagnosis and treatment of tumors of hematopoietic and lymphoid tissues

流式细胞术(FCM)在临床诊断和免疫功能评价中占据极其重要的位置。近年来随着仪器和抗体、免疫、诊疗技术的进步, FCM的临床应用也越来越广泛。《中华检验医学杂志》组织"流式细胞术在造血和淋巴组织肿瘤治疗中应用"专题报道, 多篇文章分别涵盖FCM在急性白血病免疫表型中应用、检测微小残留病、淋巴瘤诊断与随访中的应用、移植后并发症研究中的应用、免疫功能与移植后免疫重建的研究、质量控制等方面, 以期促进FCM的规范化和进一步发展。

Flow cytometry(FCM)plays an important role in clinical diagnosis and immune function evaluation.In recent years,with the progress of instruments,antibody,immunity,diagnosis and treatment technology,the clinical application of FCM is more and more extensive.Aiming to promote the standardization and further development of FCM,combined with several reports in the topic"Application of flow cytometry in the diagnosis and treatment of tumors of hematopoietic and lymphoid tissues",the paper reviews and comments in the application of FCM in acute leukemia immunophenotyping,detection of minimal residual disease,diagnosis and follow-up of lymphoma,detection of complications after transplantation,immune function and immune reconstruction after transplantation,quality control,and the prospect of FCM.