凝固曲线波形分析的临床应用

Clinical application of clot waveform analysis

出血与血栓性疾病与临床各科室密切相关, 实验室相关检测在疾病诊断和鉴别诊断、风险评估、寻因和疗效监测等方面发挥着重要作用。凝固曲线波形分析(CWA)作为一种自动化的凝血检测技术, 可以提供更多关于血浆样品整个凝血过程的宝贵信息。大量研究表明, CWA在新冠肺炎(COVID-19)患者凝血状态的评估、A型血友病(HA)患者临床表型的判断以及直接口服抗凝药(DOAC)的监测等应用中具有一定价值。在不同的临床场景中对CWA进行深入解读和应用, 可以为诊断和治疗出血与血栓性疾病提供更多的实验室信息。

Bleeding and thrombotic diseases are closely related to various clinical departments.Laboratory-related tests play an important role in disease diagnosis and differential diagnosis,risk assessment,cause finding,and efficacy monitoring.Clot waveform analysis(CWA),as an automated coagulation detection technology,can provide more valuable information about the entire coagulation process of a plasma sample.A large number of studies have showed that CWA has certain value in the evaluation of coagulation status of COVID-19 patients,the judgment of clinical phenotype of hemophilia A(HA)patients,and the monitoring of direct oral anticoagulant drugs(DOAC).In-depth interpretation and application of CWA in different clinical settings can provide more laboratory information for diagnosis and treatment of bleeding and thrombotic diseases.