痰液中生物活性物质在肺癌诊断中的作用和意义

Role and Signi?cance of Bioactive Substances in Sputum in the Diagnosis of Lung Cancer

肺癌是我国目前发病率最高的恶性肿瘤之一,其诊断的金标准需要进行组织活检的病理学检查或脱落细胞学检查,二者的有创性和敏感性限制了他们的使用。痰液中含有大量核酸、蛋白质,是肺功能的良好反映物,肺癌组织也会影响痰液中的生物成分,检测其中的生物活性物质可有助于肺癌的诊断。本文综合目前国内外的研究结果,对痰液中可用于肺癌诊断的生物活性物质做一综述。

The incidence rate of lung cancer is one of the highest incidence of malignancies in China.The gold standard for diagnosis requires pathological examination or cytological examination of biopsy.The invasive and sensitive nature of the two limits their use.Sputum contains a large number of nucleic acids and proteins,which is a good reflection of lung function.Lung cancer tissue will also affect the biological components in sputum.The detection of bioactive substances in sputum can contribute to the diagnosis of lung cancer.Based on the current research results at home and abroad,this paper reviews the bioactive substances in sputum that can be used for the diagnosis of lung cancer.