达立通颗粒联合西药治疗慢性胃炎的临床效果

Therapeutic Effect of Dalitong Granules Combined with Itopride on Chronic Gastritis

目的:探析采取达利通颗粒联合以阿莫西林为主的三联疗法治疗慢性胃炎的临床效果及对降钙素原(PCT)水平与胃泌素17(G-17)的影响。方法:选取2019年10月至2020年12月马鞍山市中心医院收治的慢性胃炎患者60例作为研究对象,按照随机数字表法随机分为对照组(奥美拉唑+阿莫西林+克拉霉素胶囊三联疗法治疗)和观察组(达利通颗粒联合奥美拉唑+阿莫西林+克拉霉素胶囊三联疗法治疗),每组30例。比较2组患者治疗总有效率、PCT水平、G-17、胃蛋白酶原(PGⅠ、PGⅡ)及不良反应发生率等指标。结果:观察组治疗有效率明显高于对照组(P<0.05);观察组PCT水平明显低于对照组(P<0.05),G-17水平明显高于对照组(P<0.05);观察组PGⅠ、PGⅡ等胃蛋白酶原指标明显高于对照组(P<0.05);与对照组比较,观察组经联合用药治疗后不良反应发生率更低(P<0.05)。结论:慢性胃炎患者采取达立通颗粒联合奥美拉唑+阿莫西林+克拉霉素胶囊三联疗法进行治疗能够有效的改善降钙素原、胃泌素等指标,还可改善血清细胞因子水平,改善胃黏膜病变,降低患者的不良反应,有着安全性高、疗效好等优势,应推广应用。

Objective:To explore the clinical effects of Dalitong Granules combined with itopride in the treatment of patients with chronic gastritis and its effect on procalcitonin(PCT)level and gastrin17(G-17).Methods:A total of 60 patients with chronic gastritis admitted to Ma′anshan Central Hospital from October 2019 to December 2020 were randomly divided into a control group(n=30,Omeprazole+amoxicillin+clarithromycin capsule)and an observation group(Dalitong Granules combined with omeprazole+amoxicillin+clarithromycin capsule),with 30 cases in each group.The total effective rate,PCT level,G-17,pepsinogen(PGⅠ,PGⅡ)and the incidence of adverse reactions were compared between the 2 groups.Results:The total effective rate of combined treatment group was significantly higher than that of the control group(P<0.05),the PCT level was significantly lower than that of the control group(P<0.05),and the G-17 level was significantly higher than that of the control group(P<0.05)PGⅠand PGⅡin the Observation Group were significantly higher than those in the control group(P<0.05),and the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Patients with chronic gastritis are treated with Dalitong Granules combined with Omeprazole+amoxicillin+clarithromycin capsule,which can effectively improve the indexes such as procalcitonin and gastrin,improve the level of serum cytokines,improve gastric mucosal lesions and reduce adverse reactions.It has the advantages of high safety and good curative effect,and should be popularized.