角质形成细胞与白癜风发病机制的相关研究进展

Research Progress of Keratinocytes and the Pathogenesis of Vitiligo

白癜风是皮肤科最常见的色素障碍性疾病,病因及发病机制尚不明确,目前多认为白癜风是一种氧化应激相关的自身免疫性疾病。近年来研究表明,角质形成细胞能够分泌多种细胞因子,并通过旁分泌作用影响黑素细胞的生物学行为和黑素合成,当其处于氧化应激状态时,可作为天然免疫细胞启动机体的免疫反应,参与白癜风的发病。该文将从细胞因子、氧化应激以及细胞免疫三个方面综述角质形成细胞在白癜风发生发展中的作用,以期为疾病的发病机制及治疗研究提供新思路。

Vitiligo is the most common pigmented disorder in dermatology,and its etiology and pathogenesis are still unclear.At present,vitiligo is considered to be an autoimmune disease related to oxidative stress.In recent years,studies have shown that keratinocytes can secrete a variety of cytokines,which affect the normal survival and melanin synthesis of melanocytes through paracrine.When they are in a state of oxidative stress,keratinocytes can act as innate immune cells to initiate the immune response of the body and participate in the pathogenesis of vitiligo.That article will review the role of keratinocytes in the occurrence and development of vitiligo from three aspects:cytokines,oxidative stress and cellular immunity,in order to provide new ideas for the pathogenesis and treatment of the disease.