基于弥散张量成像的颞叶癫痫患者脑白质纤维束完整性

White Matter Integrity in Temporal Lobe Epilepsy Patients Based on Diffusion Tensor Imaging

为了探讨颞叶癫痫(temporal lobe epilepsy,TLE)患者脑白质纤维束结构完整性的变化情况,纳入23例TLE患者和30例健康对照,对所有受试者进行弥散张量成像(diffusion tensor imaging,DTI)和结构磁共振成像(structural magnetic resonance imaging,sMRI)扫描,采用基于体素分析(voxel-based analysis,VBA)和基于fixel分析(fixel-based analysis,FBA)方法,比较2组间部分各向异性(fractional anisotropy,FA)、平均弥散率(mean diffusivity,MD)、轴向扩散率(axial diffusivity,AD)和径向扩散率(radial diffusivity,RD),纤维密度(fiber density,FD)、纤维横截面积(fiber cross-section,FC)和纤维密度与纤维横截面积(fiber density and cross-section,FDC)的差异,并分析患者脑白质改变与病程之间的相关性.与健康组相比,TLE患者的MD、AD及RD值增加,FA、FD、FC及FDC值减少.结果表明:基于fixel分析的磁共振弥散张量成像为检测癫痫患者脑白质纤维束形态学差异提供一种思路,有助于TLE诊断.

To investigate the alterations in structural integrity of white matter fiber tracts with temporal lobe epilepsy(TLE)patients,diffusion tensor imaging(DTI)and structural magnetic resonance imaging(sMRI)were performed on 23 TLE patients and 30 healthy controls subjects.The fractional anisotropy(FA),mean diffusivity(MD),axial diffusivity(AD)and radial diffusivity(RD),fiber density(FD),fiber cross-section(FC)and fiber density and cross-section(FDC)were measured and compared between the two groups by using the voxel-based analysis(VBA)and fixel-based analysis(FBA)methods.Additionally,the correlation between white matter alterations and the duration of disease were analyzed.Compared with the healthy controls group,the MD,AD and RD values of TLE patients increased;the FA,FD,FC and FDC values were reduced.Results show that FBA of magnetic resonance DTI provides a new method to show the alterations of white matter fiber tracts in the whole brain morphological,which is helpful for the diagnosis of TLE.