非小细胞肺癌中IGF1、IGFBP2表达与预后的相关性分析

Correlation analysis of IGF1,IGFBP2 expression and prognosis in non-small cell lung cancer

目的探讨非小细胞肺癌组织胰岛素样生长因子1(IGF1)、胰岛素样生长因子结合蛋白2(IGFBP2),蛋白表达与患者临床病理特征及预后的关系。方法将226例确诊的非小细胞肺癌患者癌组织为非小细胞肺癌组;选取其癌旁正常组织为癌旁对照组。检测癌组织及癌旁正常组织IGF1、IGFBP2蛋白表达水平;分析非小细胞肺癌患者癌组织IGF1与IGFBP2蛋白表达相关性及其与预后的关系;并分析影响非小细胞肺癌患者预后的因素。结果非小细胞肺癌组IGF1、IGFBP2蛋白高表达率高于癌旁对照组(P<0.05)。非小细胞肺癌患者癌组织IGF1、IGFBP2蛋白表达与肿瘤大小、淋巴结转移、组织分化程度、TNM分期有关(P<0.05)。非小细胞肺癌患者癌组织IGF1与IGFBP2蛋白表达呈正相关(r=0.472,P<0.05)。IGF1、IGFBP2高表达患者五年生存率(33.33%、29.41%)低于低表达患者(69.23%、73.33%)(P均<0.05)。IGF1高表达、IGFBP2高表达、TNMⅢ~Ⅳ期是影响非小细胞肺癌患者死亡的独立危险因素(P<0.05)。结论IGF1、IGFBP2可能在非小细胞肺癌发生发展过程中发挥重要作用,且IGF1、IGFBP2高表达与患者不良预后有关。

Objective To investigate the relationship between the expression of insulin-like growth factor 1(IGF1)and insulin-like growth factor-binding protein 2(IGFBP2)in non-small cell lung cancer(NSCLC)tissues and the clinicopathological features and prognosis of NSCLC patients.Methods The cancer tissue from 226 patients with NSCLC was selected as the NSCLC group and the adjacent normal tissues were selected as the control group.The expression levels of IGF1 and IGFBP2 proteins in cancer tissues and adjacent normal tissues were detected.The correlation between IGF1 and IGFBP2 protein expression in cancer tissues and their relationship with prognosis in NSCLC patients were analyzed,and the prognostic factors of NSCLC patients were further analyzed.Results The high expression rates of IGF1 and IGFBP2 proteins in the NSCLC group were higher than those in the precancerous control group(P<0.05).The expression of IGF1 and IGFBP2 proteins in NSCLC tissues was related to tumor size,lymph node metastasis,tissue differentiation,and TNM stage(P<0.05).There was a positive correlation between IGF1 and IGFBP2 protein expression in NSCLC tissues(r=0.472,P<0.05).The 5-year survival rate of patients with high expression of IGF1 and IGFBP2(33.33%,29.41%,respectively)was lower than that of patients with low expression of IGF1 and IGFBP2(69.23%,73.33%,respectively)(both P<0.05).High expression of IGF1 and IGFBP2 and TNMⅢ-Ⅳstage were independent risk factors for death in NSCLC patients(P<0.05).Conclusion IGF1 and IGFBP2 may play an important role in the occurrence and progression of NSCLC,and the high expression of IGF1 and IGFBP2 is associated with poor prognosis.