小檗碱可溶性粒剂的制备及室内杂草防治

Preparation of Berberine Soluble Granules and Its Effiency of Weed Control

小檗碱(Berberine)是一种从中药黄连中分离的异喹啉生物碱,具有杀菌、杀虫和除草活性.本研究采用挤压造粒法制备小檗碱可溶性粒剂,通过单因素试验对载体、分散剂、润湿剂、结剂、崩解剂等主要助剂的种类和用量进行筛选,结果发现,30%小檗碱可溶性粒剂研制的最佳配方为30%小檗碱、10%木质素磺酸钠、7%聚羧酸sp-2845w、2%聚乙烯醇盐、7%氯化钠和44%无水硫酸钠.进一步通过室内土壤处理法对狗尾草Setaria viridis L.进行防治试验,结果表明30%硫酸小檗碱可溶性粒剂的防治效果显著性优于30%盐酸小檗碱可溶性粒剂,其在弱碱性条件下(pH值为9),3,7,14 d的防效分别为74.24%,66.01%和68.17%,而且显著性抑制狗尾草的生长.

Berberine,an isoquinoline alkaloid isolated from the traditional Chinese medical plant Coptis chinensis,exhibits bactericidal,insecticidal and herbicidal activity.In order to provide theoretical support and technical guidance for the production of berberine-base pesticides,soluble granules were prepared using extrusion granulation.Through single-factor screening tests,the types and amounts of major additives(carriers,dispersants,wetting agents,binders and disintegrators)were screened and optimized.The optimized formulation of the obtained 30%berberine soluble granules was found to be 30%berberine+10%sodium ligninsulfonate+7%polycarboxylate sp-2845w+2%polyvinyl alcohol-vinylalcohol polymer+7%NaCl+44%anhydrous Na 2SO 4.Furthermore,the indoor soil treatment method was used to control green bristlegrass(Setaria viridis L.).The results showed that the control effect of 30%berberine sulfate soluble granule was significantly better than that of 30%berberine hydrochloride soluble granule.Under the condition of weak alkalinity(pH=9),the control effects were 74.24%,66.01%and 68.17%for 3,7 and 14 days,respectively,and significantly inhibited the growth of green bristlegrass.