滋阴降火法治疗42例女童特发性中枢性性早熟的临床研究

Therapy of nourishing yin and downbearing fire for idiopathic central precocious puberty in children

目的观察滋阴降火法治疗女童中枢性性早熟的疗效。方法对42例女童特发性中枢性性早熟患儿予滋阴降火中药口服,记录治疗前后的中医证候、子宫、卵巢、促性腺激素及性激素,即黄体生成素(LH),促卵泡激素(FSH),雌二醇(E2)和骨龄的变化。结果与治疗前比较,治疗后患儿的各项临床症状积分均改善,差异具有统计学意义(P<0.05);治疗后患儿子宫、卵巢容积大小均减小,差异具有统计学意义(P<0.05);治疗后患儿血清LH,FSH,E2均较治疗前下降,差异具有统计学意义(P<0.05);患儿治疗后(BA/CA)小于治疗前(BA/CA),差异具有统计学意义(P<0.05)。结论滋阴降火中药对防治女童特发性中枢性性早熟有临床疗效,能改善患儿临床症状。

Objective To observe curative effect of the Chinese medical therapy of nourishing yin and downbearing fire for idiopathic central precocious puberty in girls.Methods Forty-two girls with true idiopathic central precocious puberty were treated with Chinese medical therapy of nourishing yin and downbearing fire.The changes in TCM symptoms,size of the uterus and ovary,gonadotropins,sexhormones,i.e.,luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E2),X-ray bone age before and after the treatment were recorded.Results After treatment,the scores of clinical symptoms were significantly decreased,as compared with those before treatment(P<0.05);After treatment,serum LH,FSH and E2 levels were significantly lowered(P<0.05);The size of uterus and ovary was significantly decreased,as compared with those before treatment(P<0.05);After treatment,the bone age/chronological age values were significantly reduced(P<0.05).Conclusions The Chinese medical therapy of nourishing yin and downbearing fire,which relieves clinical symptoms,is of efficacy for children with idiopathic central precocious puberty.