炎症与动脉粥样硬化关系的研究进展

Research Progress of Relationship between Inflammation and Atherosclerosis

动脉粥样硬化(As)是动脉壁慢性炎症性疾病。其炎症过程中涉及的炎症因子、炎症信号通路介导As开始、斑块生长,加剧局部细胞凋亡、内皮新生血管形成,引起斑块破裂、血栓形成,从而加剧局部缺血及梗死。目前,与炎症相关的许多生物学标志物已被确定为检测和治疗As的新靶点。因此,未来深入研究炎症对As的影响,探索调节炎症因子基因转录的锌指转录因子——早期生长反应因子3影响As炎症损伤的具体机制,可为临床抗感染治疗提供潜在靶点,并为有效延缓或逆转As的发生及发展奠定基础。

Atherosclerosis(As)is a chronic inflammatory disease in arterial wall.The inflammatory factors and inflammatory signal pathway involved in the inflammatory process mediate the initiation of As and plaque growth,aggravate local cell apoptosis and endothelial neovascularization,cause plaque rupture and thrombosis,and aggravate local ischemia and infarction.At present,many biomarkers related to inflammation have been identified as new targets for the detection and treatment of As.Therefore,in the future,in-depth study on the effect of inflammation on As and explore the specific affecting As inflammatory injury mechanisms of zinc finger transcription factor—early growth response factor 3,which regulates inflammatory factor gene transcription,can provide potential targets for the clinical anti-inflammatory treatment and lay a foundation for effectively delaying or reversing the occurrence and development of As.